Â鶹ӳ»­´«Ã½ College of Medicine Associate Professor Claudia Andl, a throat and oral cancer researcher, is investigating how a simple probiotic could treat and prevent both conditions..

Â鶹ӳ»­´«Ã½ College of Medicine Associate Professor Claudia Andl, a throat and oral cancer researcher, is investigating how a simple probiotic could treat and prevent both conditions. The research is funded by a one-year, more than $380,000 grant from the Florida Department of Health’s Florida Cancer Innovation Fund.

Probiotics are live microorganisms — usually bacteria or yeasts — that support and strengthen health by increasing the body’s population of healthy cells. Many people take probiotics to improve gut health and digestion. Andl’s research is focused on using a healthy bacteria called Lactobacillus spp. to treat esophageal damage caused by acid reflux and improve the microbial environment in the esophagus to reduce the risk of cancer.

In patients with acid reflux — as well as gastroesophageal reflux disease (GERD), a chronic and more severe form of the digestive condition — stomach acid burns through the lining of the esophagus, causing inflammation and DNA damage to surrounding cells. Over time, those cellular changes can create a condition called Barrett’s esophagus, which increases the risk for esophageal cancer. In addition, when the throat’s bacterial environment becomes dominated by stomach acids and salts, healthy bacteria struggle to survive. Harmful bacteria take their place, causing further cell damage and inflammation that increases cancer risk. Introducing Lactobacillus spp. into disease models has solved both issues.

“We all talk about how important it is to eat yogurt or drink kombucha so that we maintain a healthy bacterial residence in all your organs. And it’s the same in the esophagus.�

“The reintroduction of beneficial bacteria works two-fold,� Andl says. “It restores a normal environment again, but also these Lactobacilli are known to suppress inflammation and repair the DNA damage.�

“We all talk about how important it is to eat yogurt or drink kombucha so that we maintain a healthy bacterial residence in all your organs,� Andl continues. “And it’s the same in the esophagus.�

Early results have shown a reduction in Barrett’s esophagus, and if cancer develops at all, it occurs much later than in models not treated with the probiotic.

Andl says she hopes her research will inform new therapies and provide more information on how to keep the body’s microbial balance healthy to fight disease. She notes this is especially important as data also shows Barett’s esophagus and esophageal cancer are increasing in patients under ages 60-70, the average age for these patient populations.

“We aim to improve outcomes for the large number of reflux patients at risk for cancer,� Andl says. “Playing a role in that would be incredibly rewarding.�

Andl joined Â鶹ӳ»­´«Ã½ in 2016 after receiving her Ph.D. in cell biology from the University Duisburg-Essen in Germany and conducting postdoctoral research at the University of Pennsylvania.

This research is sponsored by the Florida Cancer Innovation Fund and the Florida Department of Health.

±á±ð°ùÌýresearch, backed by a five-year $813,130 National Institute of Allergy and Infectious Diseases grant, found that an antimicrobial peptide naturally found in cows weakens the biofilm defenses of Klebsiella pneumoniae bacteria and destroys it.

Now in their fourth year of research, Fleeman and her lab have discovered exactly how the peptide works in findings published in PLOS Pathogens.

“Our research is very advantageous for healthcare because about 80% of bacterial infections being treated in the clinic are bacteria living in a biofilm state, which makes them resistant to virtually every antibiotic available,� she says.

The results represent a critical step to potentially applying this peptide as a therapy and eventually treating patients, as the findings show they can and kill biofilm-embedded bacteria in animal models.

Parsing out the Peptide

K. pneumoniae is found in the intestines and is usually harmless, however, the bacterium develops resistance over a person’s lifetime as they are exposed to antibiotics. The bacteria also can spread from the intestine to other parts of the body in immunocompromised patients and those who have internal ruptures or exposure to contaminated medical devices. That exposure can lead to pneumonia, urinary tract or wound infections.

“What happens is the bacteria infects the wound, proliferates, and then invades through the bloodstream where it travels to the liver, kidneys and spleen,� Fleeman says. “We found our peptide was able to decrease the bacteria at the source while limiting the bacteria’s ability to move through the blood.�

Fleeman and her lab’s most recent study found that the peptide triggers a dual stress response that tricks the bacteria to break out of their protective biofilm.

They discovered the genetics of a specific protein in the bacterium when turned on in the germ causes it to break from its own protective biofilm. The peptide, in effect, damages the protection and then stresses the bacterium into shedding its protection, making the germ more sensitive to antibiotics and the body’s immune system.

“By hitting the membrane as well as protein synthesis at the same time, it’s a double punch that triggers a genetic change in the cell to make it think it needs to break out of the biofilm as a response to our peptide,â€� Fleeman says.

The team says their sustained research aims to demonstrate that their peptide can work synergistically with existing antibiotics. They envision long-term applications could involve a topical cream that weakens the bacteria’s defenses and allows standard antibiotics to work more effectively.

“We’re moving our research forward and we’re very hopeful,� Fleeman says.

Preparing for the Post-Antibiotic Era

The first author of this new work is Robert Beckman ’23, who graduated from Â鶹ӳ»­´«Ã½Â with a bachelor’s degree in health sciences, managed Fleeman’s lab and is now on his way to the University of Michigan for his Ph.D.

His previous work as an EMT gave him firsthand exposure to infectious diseases and their impact on patients. He says helping to lead the study and working with Fleeman helped prepare him for a career in medical research.

“I have developed a strong foundation in research and gained insight into the many components that define an effective scientist,� he says. “My long-term goal is to remain in academia and eventually lead my own research lab. I plan to continue focusing on bacteriology, with a particular emphasis on pathogenic bacteria and drug discovery applications.�

Funding and Disclosure:

Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R00AI163295. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Dinender Singla, professor and head of the College of Medicine’s Division of Metabolic and Cardiovascular Sciences, developed a system that turns exosomes — vesicles that cells secrete to communicate with one another — into delivery vehicles for medical treatments.

This innovative technology, for which Â鶹ӳ»­´«Ã½ is seeking patent protection, places therapeutics inside exosomes and coats them with cell-specific markers that direct them to an exact area of the body to deliver the drug.

“I call these smart tiny bubbles,� Singla says. “Millions of people have heart disease, and they take multiple drugs in extremely high doses. But we have no way to be certain these drugs are getting to where they need to go. We need innovative technologies to get treatments exactly where they need to go to cure the problem.�

How the Therapy Works

This discovery is part of Singla’s work to provide therapies to treat and prevent heart disease, including heart damage caused by cancer treatments such as chemotherapy and targeted radiation to the chest. That heart damage seems to be caused by inflammatory factors that treatments use to kill cancer cells. Technology developed by Singla encapsulates anti-inflammatory heart treatments in exosomes and then delivers the drug to the exact area of heart damage.

“They can treat cancer and protect the heart.â€� — Â鶹ӳ»­´«Ã½ Professor Dinender Singla

As part of this research, Singla’s team also developed technologies to deliver cancer-killing drugs inside exosomes. They chose triple-negative breast cancer for their research, the deadliest form of the disease, with a 77%–78% five-year survival rate. In the lab, the therapy showed significant promise in killing cancer cells – at much lower doses that are used in chemotherapy – while also protecting the heart. So the exosome therapy could help cancer patients without the severe side effects of chemotherapy.

“These therapies can work hand-in-hand,� Singla said. “They can treat cancer and protect the heart.�

Financial Investment is Key for Drug Development

The next step will be manufacturing the therapy for clinical use and advancing into FDA clinical trials for heart disease and cancer treatment. To help accelerate that path, Singla partnered with Orlando investor and Â鶹ӳ»­´«Ã½ donor Chakri Toleti, a healthcare technology entrepreneur focused on building category-defining businesses through AI and agentic platforms, biomedical innovation and ambient intelligence including most recently care.ai, which was acquired by Stryker in 2024.

Through his innovation fund, TCapital, Toleti backs transformative technologies designed to improve healthcare delivery and reduce human suffering at scale. Together, Singla and Toleti invested in and formed Exomic to fund continued research, clinical development, and commercialization of the technology.

“This was an opportunity to do something truly innovative in cancer and cardiovascular treatment.â€� — Chakri Toleti, Â鶹ӳ»­´«Ã½ donor

Toleti says his passion for advancing cancer research is deeply personal after losing his father to the disease.

“This was an opportunity to do something truly innovative in cancer and cardiovascular treatment,� he says. “Dr. Singla’s work represents a fundamental shift toward new biomedical platforms not only in how targeted therapies are delivered in the human body, but in how we think about treatment and healing itself.�

Such public-private partnerships are one of the goals of , which drives innovation, enterprise, and collaboration across disciplines.

“Dr. Singla’s groundbreaking exosome delivery system perfectly exemplifies how university innovation translates into significant, life-saving benefits for society,� says Winston V. Schoenfeld, vice president for research and innovation. “As demonstrated by the creation of Exomic, industry partnership is essential for driving such pioneering technologies towards successful translation and real-world clinical use.�

The effort is also providing exciting learning opportunities for College of Medicine graduate students. Jonatas De Mendonca Rolando ’23MS ’26PhD earned his Ph.D. in biomedical sciences earlier this month. He is staying at Â鶹ӳ»­´«Ã½ as a post-doctoral researcher to continue creating the exosome therapy.

He helped develop protocols and procedures for the delicate technology and saw its impact in the lab. He’s excited to have a financial supporter who can help take the therapy from lab to, he hopes, patients.

“It’s been amazing to part of a high-tech project and see leadership in science,� he says. “I am very excited for my future.�

Researcher Background

Singla is the AdventHealth Endowed Chair of Cardiovascular Sciences at the Burnett School of Biomedical Sciences and is a faculty fellow with the Â鶹ӳ»­´«Ã½ Office of Research. He earned his bachelor’s and master’s degrees from Punjabi University, Patiala, India, and his Ph.D. from the Post Graduate Institute of Medical Education and Research, Chandigarh, India. He has published more than 100 peer-reviewed papers and has continually been funded by the American Heart Association and/or the National Institutes of Health since 2004.

About TCapital

TCapital is an AI, Frontier Tech and Life Sciences innovation fund investing in category-defining platforms and infrastructure. Founded by healthcare technology entrepreneur Chakri Toleti, T-Capital invests in companies shaping the future of treatment, care, and biomedical innovation. For more information, visit TCapital.com.

All were among 109 College of Medicine graduates who became Physician Knights on May 15 and promised to become what their dean calls one of “the Good Doctors – a Â鶹ӳ»­´«Ã½ tradition.â€�

This year’s M.D. program commencement was the medical school’s 14th and the last for Vice President for Health Affairs and founding Dean Deborah German, who announced earlier this year she will transition from the role she has held for 20 years.

“Graduates, today you become alumni of an innovative medical school committed to improving health for all,� she said. “Through your time here, you learned, you grew, and you cared for patients with courage, dedication, and grace. I couldn’t be prouder of the work you have done.�

With this year’s commencement, Â鶹ӳ»­´«Ã½â€™s young medical school, which opened in 2009, has prepared 1,421 physicians to care for Floridians and the nation at large.

Inspired by Her Research Mentor

Moots is the third M.D./Ph.D. graduate in Â鶹ӳ»­´«Ã½â€™s history. She enrolled at the university in 2013 to pursue her bachelor’s degree in biomedical sciences and began her combined doctoral degree in 2018. Now she will go to Lakeland Regional Hospital for internal medicine training – her first choice for residency because of the hospital’s focus on innovation, research and clinical trials.

“I’ve spent almost half my life at Â鶹ӳ»­´«Ã½,â€� she says. “Graduating is incredibly exciting, but it feels strange to close such a long and meaningful chapter.â€�

She said her medical training at Â鶹ӳ»­´«Ã½ was most shaped by her research mentor, Otto Phanstiel, a College of Medicine cancer researcher. “He exemplifies the qualities I aspire to carry into medicine through the way he communicates, collaborates, and approaches every interaction with humility, curiosity, and a drive for excellence,â€� she says. “His influence has shaped how I hope to approach research, teamwork, and patient care throughout my career.â€�

“Most Monumental Moment of My Life�

Shaylor will do his . He hopes to become a hand surgeon. Medical school military officers are promoted when they receive their M.D. degree, and Â鶹ӳ»­´«Ã½â€™s tradition is to honor that promotion at commencement. After receiving their diplomas, military officers are pinned with their new rank by a faculty member of their choosing.

Shaylor was inspired to enter military service by Jose Borrero, a U.S. Air Force flight surgeon during Vietnam before becoming a founding faculty member at the College of Medicine. Now retired, Borrero continues to serve as a mentor to Â鶹ӳ»­´«Ã½ medical students. He returned to commencement May 15, pinned Shaylor and proudly saluted the young military physician. Shaylor describes the pinning as “the most monumental moment of my life.â€�

Connecting with Others

Castellano and Threatt met playing volleyball during their first year of medical school, then started a band with other M.D. students. They went through the fear of “couples matching� into residency – unsure if they would be selected to train at the same hospital or even city.

Today they’re simultaneously planning their move to Johns Hopkins in Baltimore and their wedding. He’ll practice anesthesiology because it combines his love of chemistry and connecting with people.

“There’s a small window that you have to talk to patients before surgery, but it is one of their most vulnerable moments in which you really have an ability to make this individual feel comfortable,� he says. “That is a very special relationship to me.�

She’s training to be a pediatrician.

“My biggest dream and aspiration is to be an advocate for children and for families,� she says. “I think that through Johns Hopkins there will be a lot of opportunities to do so and go into communities to be helping and educating children.�

When NASA launches its latest voyage to the International Space Station on May 12, it will carry a blood clotting experiment from the Â鶹ӳ»­´«Ã½ College of Medicine’s newest faculty member. The research will include illuminated bone marrow cells floating in space to find better ways to keep astronauts and Earthlings healthier.

Hansjorg Schwertz specializes in occupational health and focuses his research on how microgravity and radiation in space impact the body’s blood-clotting functions. After an extensive career overseas and at the University of Utah, he comes to Â鶹ӳ»­´«Ã½ to serve as the associate director for Translational Aerospace Medicine Research at the Â鶹ӳ»­´«Ã½ Center for Aerospace and Extreme Environments Medicine (CASEEM).

As humans prepare for longer missions to the moon, Mars and beyond, the center is exploring how factors such as microgravity, radiation and isolation impact the human body in space and how that knowledge can drive innovation into diagnostics, treatment and disease prevention for patients on Earth.

“When it comes to putting footprints on the moon, there is no better place to be than Â鶹ӳ»­´«Ã½,â€� he says.

NASA Concerned About Blood Clots in Space

Pre- and post-mission medical testing of astronauts on the International Space Station has shown that spaceflight changes their immune system and blood clotting ability. A few astronauts have even developed blood clots during a flight or after returning. For that reason, Schwertz is leading the NASA-funded Megakaryocytes Orbiting in Outer Space and Near Earth (MOON) study, which he began working on at the University of Utah and continues to collaborate with the university’s researchers on.

“When it comes to putting footprints on the moon, there is no better place to be than Â鶹ӳ»­´«Ã½.â€� — Hansjorg Schwertz

Megakaryocytes are bone marrow cells that create platelets, which circulate in the blood stream and can stop bleeding or form blood clots. Both cells also play a key role in immune responses.

The MOON study is examining how space flight affects the development and function of megakaryocytes as they create platelets. The results could provide important knowledge about the risks of inflammation, immune responses and blood clot formation that will help space travelers and patients on Earth, Schwertz says.

His team is sending human cells to the ISS on board the SpaceX 34 resupply mission. Once they are aboard the space station, astronauts will culture the cells and help to develop megakaryocytes in space.

One part of the experiment is to watch the cells in real time, and how they develop their “daughter cell,â€� the platelets. Because the research will be in microgravity, the cells will float. They’ll be stained with fluorescent dye so Â鶹ӳ»­´«Ã½â€™s researcher can examine them remotely at better accuracy.

Schwertz says mentors taught him, “seeing is believing,� so he is “genuinely excited� to see megakaryocytes float in space.

Advancing Personalized Medicine

One of the challenges of space medicine research is that so few people have gone to space, so the sample pool is small. As space travel and colonization progress, more people will be traveling to and working on the moon and beyond.

Healthwise, many will be different than astronauts who are selected after going through vigorous testing and selection criteria. Thus, space is a new frontier of healthcare.

Schwertz hopes his study will unlock technologies and therapies to keep astronauts’ blood clotting mechanisms controlled, prevent abnormal clotting and bring those discoveries back to Earth.

“We’re examining the impact of space flight on each person’s cells,� he says. “This is personalized medicine, and isn’t that what healthcare is all about?�

Emmanuel Urquieta, vice chair for Aerospace Medicine at the Â鶹ӳ»­´«Ã½ College of Medicine and founding director of CASEEM, Schwertz’s work reflects the program’s broader mission to connect spaceflight research with practical clinical and operational solutions.

“Our aerospace medicine program is intentionally designed to be operational and translational in nature,� Urquieta says. “We are building a program that can support the real medical needs of exploration missions while rapidly translating discoveries from spaceflight and extreme environments into innovations that improve health here on Earth.�

Schwertz received his M.D. and Ph.D. from the School of Medicine at the University of Mainz, Germany. After a residency in Internal Medicine/Cardiology at the University of Halle, Germany, he did a post-doctoral fellowship at the University of Utah, where he also served as faculty.

In 2012, he  was awarded a prestigious Lichtenberg-Professorship for Experimental Hemostasis and returned to Germany where he directed a research laboratory. He returned to Utah in 2015, where he completed his residency training in Occupational Medicine and was a faculty member, researcher and community physician.

The material is based upon work supported by NASA under award No. 80NSSC22K0255. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Aeronautics and Space Administration.

Â鶹ӳ»­´«Ã½ is the leading producer of talent among Florida’s universities, awarding nearly 19,000 degrees annually to Knights who go on to work in high-demand industries. About 85% of our alumni stay in Florida because of the ample opportunity to thrive as part of our state’s workforce.

Graduates will hear from six esteemed speakers whose leadership and impact span some of Central Florida’s most influential industries:

• Barry Miller ’95, president of Voloridge Investment Management
• Brian Adams ’04MBA, president and CEO of AdventHealth Central Florida Division
• Gloria Caulfield, vice president of strategic alliances, Tavistock Development Company
• Barbara Gellman-Danley, president of Higher Learning Commission
• Maj. Gen. James Smith, commander, space training and readiness command at Patrick Space Force Base
• Peter Lee, president of Microsoft Science

Commencement Festivities

Held in the Addition Financial Arena, spring commencement will take place over six ceremonies spanning Friday, May 8, and Saturday, May 9.

All guests, including children and infants, need a ticket for admission. All graduates who have filed an intent to graduate will receive five commencement ceremony tickets when they pick up their regalia packet.

Guests who do not have tickets may watch the live ceremony via a simulcast viewing in the FAIRWINDS Alumni Center and the Student Union. Ceremonies will also be livestreamed .

Commencement Photo-ops Across Â鶹ӳ»­´«Ã½

Graduating Knights are unable to take photos at the Acrisure Bounce House Stadium this semester due to ongoing construction.

Grad Walk

On Thursday, May 7, 2:30-7 p.m. (doors close at 6 p.m.), spring graduates are invited to a photo-op — Grad Walk — within the Addition Financial Arena. This will be a first-come, first-served occasion for graduates and up to 10 of their well-wishers to take photos and videos on the ceremony stage. Graduates are required to .

Commencement Schedule

Graduates and guests can review the below commencement ceremony schedule, listing colleges, ceremony dates and streaming links:

Friday, May 8

9 a.m.

College of Business

Rosen College of Hospitality Management

2 p.m.

College of Health Professions and Sciences

College of Medicine

College of Nursing

7 p.m.

College of Arts and Humanities

Nicholson School of Communication and Media

Saturday, May 9

9 a.m.

College of Community Innovation and Education

2 p.m.

College of Sciences (excluding Nicholson School of Communication and Media)

7 p.m.

College of Engineering and Computer Science

College of Graduate Studies

College of Optics and Photonics

For more details and FAQs about Spring 2026 commencement celebrations, visit ucf.edu/graduation.

Commencement Speakers

Barry Miller ’95

President of Voloridge Investment Management

Barry Miller ’95 serves as president of Voloridge Investment Management, quantitative hedge fund manager, and Voloridge Health, a data science-based health tech company, both Florida based.

Miller, who graduated with honors from Â鶹ӳ»­´«Ã½ with a bachelor’s degree in finance, recently made a transformational $50 million gift this spring to establish the Barry S. Miller College of Business at Â鶹ӳ»­´«Ã½. The largest single philanthropic investment in Â鶹ӳ»­´«Ã½ history, the gift will accelerate a bold new model of business education designed for a world where technology, data and decision-making are inseparable.

Miller, also a member of the Â鶹ӳ»­´«Ã½ College of Business Hall of Fame, brings years of executive experience, having previously served as CEO of LASAS Technologies, a finance and insurance company that he co-founded in 1998. His career experience includes financial analysis, capital raising, financial markets, actuarial experience, software development and in-depth company infrastructure formation.

After gaining valuable experience as an entrepreneur and chief executive officer, Miller’s ambition led him to join and invest in Voloridge Investment Management and then Voloridge Health. For both companies, he is responsible for many facets of leadership, including trading, back-office operations, compliance, sales and marketing, vendor relationships and strategic planning.

Brian Adams ’04MBA

President and CEO of AdventHealth Central Florida Division

Brian Adams is president and CEO of AdventHealth’s Central Florida Division, one of the nation’s largest faith-based health systems, whose 37,000 dedicated team members provide care for more than 3 million patients.

Known for building high-performing teams and ensuring the organization grows to meet the care needs of the community, Adams has led efforts to expand access to care, elevate quality and bring innovative solutions to rapidly growing communities. His leadership has continued to position AdventHealth as a trusted and innovative partner in Central Florida.

As a part of AdventHealth for more than 24 years, Adams has held senior leadership roles across the organization, including CEO positions in Tampa and Polk County, where he oversaw major expansions, facility investments and quality improvements.

He earned his master’s of business administration from the Â鶹ӳ»­´«Ã½ and a bachelor’s degree from Union College in Nebraska. Originally from Oshawa, Ontario, Canada, Adams and his wife have two teenage sons.

Gloria Caulfield

Vice president of strategic alliances, Tavistock Development Company

In her multifaceted role as vice president of strategic alliances at Tavistock, Gloria Caulfield manages business development and corporate partnerships, collaborates with national and global stakeholders to advance health innovation, and leads the development of cutting-edge strategies for the Lake Nona community.

She is the chief architect and creative force behind the Lake Nona Impact Forum. The revered global health innovation summit brings together many of the world’s most preeminent thought leaders and serves as a signature event of the Tavistock Group.

Caulfield serves on boards that reflect her passion for advancing the future of human health, including the StartUp Health Impact Board, which focuses on mobilizing entrepreneurs to solve the biggest health challenges of our time, and the LFE Capital Advisory Board, which supports female founders and impactful, wellness-oriented companies.

Prior to joining Tavistock, she had a distinguished career at AdventHealth. As senior executive director for community development, she provided strategic leadership for corporate partnerships and spearheaded critical community initiatives across Central Florida. Caulfield is an alumna of the University of Arizona and brings visionary leadership to every aspect of her work.

Barbara Gellman-Danley

President of Higher Learning Commission

Barbara Gellman-Danley is president of the Higher Learning Commission, which accredits colleges and universities to ensure they meet high-quality standards and continuously improve.

Prior to beginning this role in 2014, she was president of the University of Rio Grande/Rio Grande Community College in Ohio. She previously served as vice chancellor of the Ohio Board of Regents, president of Antioch University McGregor, vice president at Monroe Community College and vice chancellor at the Oklahoma State Regents for Higher Education.

Gellman-Danley sits on the boards of Credential Engine, which she chairs, and GlobalMindED. Her career includes previous board and commission memberships with the Association of Governing Boards Council of Presidents, the National Council for State Authorization Reciprocity Agreements, the American Council on Education’s Education and Attainment group and the Council on Adult and Experiential Learning.

Gellman-Danley holds degrees from Syracuse University, Simmons University, Oklahoma City University and the University of Oklahoma. She did post-graduate work at New York University, Cornell, Harvard, the University of Chicago and MIT.

An honorary member of Phi Theta Kappa, she is a professional certified coach, certified executive coach and certified life coach. She holds certifications in change management, Agile and Lean Six Sigma, a professional credential validating expertise in data-driven process improvement aimed at reducing waste and defects.

Maj. Gen. James Smith

Commander, space training and readiness command at Patrick Space Force Base

As commander, Maj. Gen. James E. Smith is responsible for preparing the U.S. Space Force and more than 14,000 military and civilian guardians to prevail in competition and conflict through innovative education, training, doctrine and test activities.

Originally from Boise, Idaho, Maj. Gen. Smith commissioned in 1997 as the top graduate of the U.S. Air Force Academy. His career spans numerous space operations and acquisition positions, including command at the squadron, group, wing, garrison and Field Command levels.

Maj. Gen. Smith has deployed to Afghanistan in support of Operation Enduring Freedom and to the U.S. Embassy in Iraq in support of Operation Inherent Resolve. Prior to his current position, Maj. Gen. Smith served as the vice director, Joint Force Development, J-7, the Joint Staff, Arlington, Virginia.

Peter Lee

President of Microsoft Science

Peter Lee is president of Microsoft Science, where his responsibility is to accelerate the pace of discovery in the physical, biological and medical sciences through the use of artificial intelligence and other emerging technologies.

Previously, he led the world laboratories of Microsoft Research. Before joining Microsoft in 2010, he established a new technology office at the Defense Advanced Research Projects Agency within the U.S. Department of Defense, creating operational capabilities in machine learning, data science and computational social science.

From 1987 to 2010, Lee was a professor and the head of the computer science department at Carnegie Mellon University. He is a member of the National Academy of Medicine and serves on the boards of several institutions in AI and medicine, including the board of trustees of the Mayo Clinic and the board of directors of the Kaiser Permanente School of Medicine. He served on President Obama’s Commission on Enhancing National Cybersecurity and has testified before both U.S. House and Senate committees.

He is the co-author of the book, The AI Revolution in Medicine: GPT-4 and Beyond. In 2024, Lee was named by Time magazine as one of the 100 most influential people in health and life sciences.

Four outstanding undergraduate students are redefining the boundaries of STEM through their high-impact research — and in doing so, placing the university among the nation’s top producers of Goldwater Scholars.

The prestigious Goldwater Scholarship identifies and supports the nation’s best student researchers in the fields of engineering, mathematics and natural sciences.

This year’s honorees — all expected to graduate next spring — have propelled Â鶹ӳ»­´«Ã½ into an elite tier of research institutions, surpassing several Ivy League institutions and tying for fourth in the nation in total Goldwater Scholars produced alongside Stanford University, the University of Notre Dame and the University of Chicago. Their impactful work reflects Â鶹ӳ»­´«Ã½’s commitment to building a high-level research environment that empowers students to lead projects addressing significant global and scientific challenges.

Supporting Space Exploration

Goldwater Scholar: Keanu Brayman

Major: Mechanical engineering

Ultimate Goal: To develop robotic systems to support human exploration on Mars.

Keanu Brayman’s passion for space began early.

“One of my earliest memories is watching a Space Shuttle streak across the sky from a beach in South Florida,� Brayman says. “I remember being amazed there were people on board and feeling drawn to one day help explore the stars and discover what lies beyond our planet.�

At Â鶹ӳ»­´«Ã½, Brayman has refined that dream with the support of faculty and mentors — including Department of Physics Chair and Professor Adrienne Dove, Associate Professor of Mechanical and Aerospace Engineering Tarek Elgohary and NASA Marshall Space Flight Center Engineer Christopher Proctor — as well as through programs like the .

He plans to pursue a doctoral degree in aerospace engineering to support lunar exploration and NASA’s Artemis program, as well as develop robotic systems that can extract resources and build infrastructure to support human exploration on Mars.

Engineering the Brain

Goldwater Scholar: Kyle Coutray

Majors: Computer engineering and biomedical sciences

Ultimate Goal: To research ways to restore communication, movement and cognitive function to the brain through engineering methods.

Kyle Coutray is focused on the intersection of neuroscience and technology.

“I’m interested in building systems that interact directly with the brain,� Coutray says. “In the lab, … [I’m] blending [both majors] into one approach.�

He aims to pursue a doctoral degree in neural engineering to further his research on brain-computer interfaces that translate complex brain activity into useful functions.

A 2026 Order of Pegasus inductee and a Burnett Honors Scholar, Coutray credits his success to disciplined focus and strong mentorship, particularly from Charles N. Millican Professor of Computer Science Joseph LaViola and Associate Professor of Mechanical and Aerospace Engineering Helen Huang.

Advancing Patient Care

Goldwater Scholar: Varun Nannuri

Major: Molecular and cellular biology

Ultimate Goal: To pursue a career as a physician-scientist.

Varun Nannuri is driven by a desire to understand why people experience different health outcomes and improve care.

“Through my clinical experiences, I have seen how much patients and families rely on physicians during some of the most difficult moments of their lives,” Nannuri says. “My research experiences have shown me that better care depends on asking better questions.”

Nannuri plans to pursue a dual M.D./Ph.D. degree and become a physician-scientist. His ambition earned him recognition as a 2026 Order of Pegasus inductee while also completing his Honors Undergraduate Thesis. Nannuri is also a member of the Burnett Honors College as a Burnett Medical Scholar, a program that offers guaranteed admission to the Â鶹ӳ»­´«Ã½ College of Medicine upon completion.

“Â鶹ӳ»­´«Ã½ has given me opportunities to grow as a student, researcher, leader and future physician,â€� Nannuri says.

Restoring Human Senses

Goldwater Scholar: Trevor Overton

Majors: Electrical engineering and biomedical sciences

Ultimate Goal: To improve the lives of people with disabilities through advanced robotic prostheses.

Burnett Honors Scholar Trevor Overton’s work centers on neuroengineering and next-generation prosthetics.

“I’ve always had a passion for building things, and I also love reading and watching sci-fi,â€� Overton says. “When Â鶹ӳ»­´«Ã½ offered me the opportunity to join the MEDD [ … I knew I had to take it.â€�

Â鶹ӳ»­´«Ã½â€™s MEDD program provides scientifically driven students like Overton with a unique opportunity to integrate engineering principles into medicine.

Much like the development of cochlear implants, Overton imagines similar breakthroughs with vision and touch.

“I envision a future where robotic prostheses are so advanced that they could completely replace or enhance the abilities of humans,� Overton says. “It’s not entirely impossible.�

After earning a doctoral degree in electrical engineering with a focus on neuroengineering, he hopes to inspire the next generation — just as his professors inspired him — emphasizing that Â鶹ӳ»­´«Ã½â€™s strength lies in professors who actively invest in their students.

A Growing Research Powerhouse

With four 2026 Goldwater Scholarship recipients, Â鶹ӳ»­´«Ã½ continues to strengthen its position as a leader in undergraduate research. The achievement reflects both students’ immense dedication and a university-wide commitment to driving innovation, mentorship and hands-on discovery. As these Knights prepare for the next steps in their academic journeys, they carry forward a shared mission: to turn research into real-world impact.

Students interested in applying for the Goldwater Scholarship or other major national awards should contact the Office of Prestigious Awards at opa@ucf.edu.

They proclaimed there is no better place than Â鶹ӳ»­´«Ã½, the closest medical school to Kennedy Space Center, to create a new frontier in healthcare as humans prepare for longer missions to the moon, Mars and beyond.

“You are in a global destination for medical innovation,â€� Michal Masternak told participants in the Star Nona 2026 event in Lake Nona’s Medical City. An anti-aging and cancer researcher at the Â鶹ӳ»­´«Ã½ College of Medicine, Masternak organized the event as part of the Lake Nona Research Council, which is focused on encouraging interdisciplinary scientific partnerships between industry, academia and healthcare.

Space medicine is one of the council’s priorities. Deep space travel and the commercialization of space bring unique health challenges that science is just beginning to explore. The College of Medicine’s focuses on how factors such as microgravity, radiation and isolation impact the human body in space and how that knowledge can drive innovation into diagnostics, treatment and disease prevention for patients on Earth.

Former NASA Administrator and U.S. Senator Bill Nelson told attendees the Artemis voyage’s return to the moon should inspire space medicine experts to make new discoveries.

“We’re in a whole new era, an exciting era, of space exploration that makes this time so special,� Nelson said.

Star Nona’s goal was to bring together experts to understand current research on the health impacts of space travel and what challenges need to be addressed as more professional and commercial space travelers go to the moon and beyond.

The Physical Challenges of Space Flight

Former NASA astronaut Robert Curbeam holds the record for most spacewalks on a single mission. He described how the body feels during launch and splashdown when G-forces are so strong you must remind yourself to breathe. He presented with his former NASA flight surgeon, Smith Johnson, now a faculty member at Â鶹ӳ»­´«Ã½â€™s new Center for Aerospace and Extreme Environments Medicine (CASEEM). The two discussed the important relationship between physicians and space travelers before, during and after a mission.

“I loved being an astronaut and flying space shuttles,� Curbeam says. “The only problem with space travel is that not a lot of people get to do it.�

Your Brain Actually Shifts in Space

Living in space causes the body’s fluids to move up to the head and brain. But symptoms of that condition do more than cause puffy faces. Space travel actually causes the brain to shift. Jogi Pattisapu, of the Hydrocephalus and Neuroscience Institute, said as astronauts go to Mars for years-long missions and settle on the moon, scientists will have to understand how living in space affects brain function and create predictive tests and preventative measures. Eye health will be key, as fluid buildup has caused spaceflight-associated neuro-ocular syndrome (SANS) in 70% of astronauts on the International Space Station, leading to farsightedness, optic nerve swelling and eyeball flattening.

“What are we going to do if the pilot goes blind 210 million miles from Earth?� he said.

Team Dynamics in Space

Interpersonal communication is key to any team’s success, but how do relationships change for crews in confined spaces and face additional challenges such as sleep deprivation, isolation and differences in rank and roles. Shawn Burke and Stephen Fiore from Â鶹ӳ»­´«Ã½â€™s Institute for Simulation and Training have researched team dynamics in space to understand and prevent collaboration failures that can impact mission success.

Their research has also identified the formal and informal roles crew members play in encouraging positive social interactions and teamwork, especially in long-term missions. Missions to Mars may take up to 36 months and include 20-minute communications delays to and from Mission Control. Team dynamics will impact performance, mental health and affect, Burke said, because “you’re stuck with the people you have.�

Conducting Medical Research in Microgravity: Everything’s Upside Down

The weightlessness of space provides a unique research environment for new discoveries in areas including nutrient production, waste treatment, crystallization and biomanufacturing, said Alain Berinstain, director of the Florida Space Institute at Â鶹ӳ»­´«Ã½.

“Terrestrially, whenever space can make a difference, it’s a great economic driver,â€� he said.

In space, air doesn’t slow down processes, he explained, so experiments that involve weight, separation, sedimentation, fluid flow and buoyancy change. His advice to researchers considering space as a lab?

“Turn your experiment upside down. Does it still work? If the answer is no, you have a lot of work to do.�

Over the course of nearly a full academic year, peers, departmental and college leadership, and the university promotion and tenure committee engaged in a rigorous, multi-stage review to ensure candidates met Â鶹ӳ»­´«Ã½â€™s high standards in teaching, research, and service. Ultimately, they recommended 100 faculty members for promotion, including 23 for tenure.

Following the review process, the president and provost make final decisions on promotions, while the Â鶹ӳ»­´«Ã½ Board of Trustees provides final approval for tenure candidates. These decisions directly advance Â鶹ӳ»­´«Ã½â€™s strategic plan and its focus on recruiting and retaining highly qualified faculty – especially those who elevate student success, accelerate discovery and research, and strengthen the talent pipeline that drives innovation and economics for the state of Florida.

“At Â鶹ӳ»­´«Ã½, promotion and tenure reflects a thoughtful, rigorous review process and the high standards we set as an institution and state,â€� says John Buckwalter, provost and executive vice president for academic affairs. “It’s a significant moment for these faculty, not just for the years of hard work it recognizes, but for what promotion and tenure represents: a sustained commitment to excellence, a deep dedication to student success, research that boldly improves lives, and the future we’re building together.â€�

Promotions and tenure conferrals annually take effect on Aug. 8.

The faculty members recognized below represent the continued strength and momentum of Â鶹ӳ»­´«Ã½.

Promotion to Associate Professor with Tenure

• John Gardiner, College of Arts and Humanities
• Tadashi Ishikawa, College of Arts and Humanities
• Sara Raffel, College of Arts and Humanities
• Jeffery Redding, College of Arts and Humanities
• John Bush, College of Business
• Seongho An, College of Community Innovation and Education
• Cynthia Williams, College of Community Innovation and Education
• Jiannan Chen, College of Engineering and Computer Science
• Chinwendu Enyioha, College of Engineering and Computer Science
• Ozlem Garibay, College of Engineering and Computer Science
• Yao Li, College of Engineering and Computer Science
• Miguel Bandres, College of Optics and Photonics
• Robert Fitak, College of Sciences
• Shyam Kattel, College of Sciences
• Kelsey Larsen, College of Sciences
• Kangsang Lee, College of Sciences
• Xialing Lin, College of Sciences
• Emily Zavodny, College of Sciences
• Kayode Aleshinloye, Rosen College of Hospitality Management
• Carissa Baker, Rosen College of Hospitality Management
• YunYing Zhong, Rosen College of Hospitality Management

Promotion to Associate Professor of Medicine with Tenure

• Taj Azarian, College of Medicine
• Thomas Kean, College of Medicine

Promotion to Professor (Tenured)

• Thaddeus Anderson, College of Arts and Humanities
• Ann Gleig, College of Arts and Humanities
• Lanlan Kuang, College of Arts and Humanities
• Sandra Sousa, College of Arts and Humanities
• Mel Stanfill, College of Arts and Humanities
• Melanie Guldi, College of Business
• Xin He, College of Business
• Laurie Campbell, College of Community Innovation and Education
• Eric Merriam, College of Community Innovation and Education
• Woo Hyoung Lee, College of Engineering and Computer Science
• Thomas Wahl, College of Engineering and Computer Science
• Yang Yang, College of Engineering and Computer Science
• Jacqueline Towson, College of Health Professions and Sciences
• Romain Gaume, College of Optics and Photonics
• Jacopo Baggio, College of Sciences
• Matthieu Baudelet, College of Sciences
• Karin Chumbimuni Torres, College of Sciences
• Geoffrey Cook, College of Sciences
• Amy Donley, College of Sciences
• Hsin‑Hsiung Huang, College of Sciences
• Brigitte Kovacevich, College of Sciences
• Arkadiy Lyakh, College of Sciences
• Peter Smith, College of Sciences
• Xiaohu Xia, College of Sciences

Promotion to Associate Professor of Medicine

• Maria Farooq, College of Medicine

Promotion to Clinical Associate Professor of Medicine

• Naziha Slimani, College of Medicine
• Sharon Wasserstrom, College of Medicine

Promotion to Clinical Professor of Medicine

• Mariana Dangiolo, College of Medicine

Promotion to Research Associate Professor

• Crystal Maraj, Office of Research

Promotion to Associate Lecturer

• Jonathan Barker, College of Arts and Humanities
• Sara Willox, College of Business
• Elizabeth Yost, College of Business
• Michael Gilbrook, College of Community Innovation and Education
• Alison Redd, College of Health Professions and Sciences
• Michael Redd, College of Health Professions and Sciences
• Michael Chetta, College of Sciences
• Heather Edwards, College of Sciences
• Seongchun Kwon, College of Sciences
• Adam Parrish, College of Sciences
• Jamie Vega, College of Sciences
• Tong Wan, College of Sciences
• Rong Zhou, College of Sciences

Promotion to Senior Lecturer

• Christy Flanagan‑Feddon, College of Arts and Humanities
• David Head, College of Arts and Humanities
• Deborah Leitch, College of Arts and Humanities
• Amanda Snyder, College of Arts and Humanities
• Jeanine Viau, College of Arts and Humanities
• Constance Goodman, College of Community Innovation and Education
• Daniel Stephens, College of Community Innovation and Education
• Shane Trenta, College of Community Innovation and Education
• Marino Nader, College of Engineering and Computer Science
• Sudeshna Pal, College of Engineering and Computer Science
• Rachid Ait Maalem Lahcen, College of Sciences
• Cynthia Bayer, College of Sciences
• Martha Hubertz, College of Sciences
• Tamra Legron‑Rodriguez, College of Sciences
• Hyung Park, College of Sciences
• Widaad Zaman, College of Sciences

Promotion to Associate Instructor

• Meeghan Faulconer, College of Arts and Humanities
• Yukari Nakamura, College of Arts and Humanities
• Carolina Salazar, College of Arts and Humanities
• Punam Desormes, College of Health Professions and Sciences
• Jorri Bright, College of Sciences
• Richard Hall, College of Sciences
• Nicholas Zuccarello, College of Sciences

Promotion to Senior Instructor

• Rita De Luca Guerriero, College of Arts and Humanities
• Steven Ton, College of Community Innovation and Education
• Todd Fix, College of Health Professions and Sciences
• Julie Matura, College of Health Professions and Sciences
• Lance Speere, College of Sciences
• Abigail Ferreira, Â鶹ӳ»­´«Ã½ Global

Promotion to Associate Instructional Designer

• Rebecca McNulty, Division of Digital Learning

Promotion to Senior Instructional Designer

• Amy Sugar, Division of Digital Learning

Promotion to Associate Librarian

• Renee Montgomery, Â鶹ӳ»­´«Ã½ Libraries

Promotion to University Librarian

• Sai Deng, Â鶹ӳ»­´«Ã½ Libraries
• Sarah Norris, Â鶹ӳ»­´«Ã½ Libraries
• Andrew Todd, Â鶹ӳ»­´«Ã½ Libraries

Nearly half of the world’s citizens live in areas with a risk of catching dengue fever, according to the Centers for Disease Control and Prevention. As the mosquito-borne illness rapidly spreads, especially in the Americas and Caribbean, a  researcher is playing a crucial role in finding solutions.

James Earnest, an assistant professor at the Burnett School of Biomedical Sciences, is leading two new research projects to examine how humans build an immune response to dengue and the Zika virus over time, in pursuit of creating better preventative measures.

Tackling a Global Problem

Both dengue and Zika are carried by the Aedes aegypti mosquito, which has expanded its habitat from Africa to tropical, subtropical and even temperate areas worldwide. According to the World Health Organization, dengue infections in humans climbed from 505,430 in 2000 to 14.6 million in 2024, an increase of more than 2,700%.

Dengue can be asymptomatic or cause severe pain, fatigue and high fever. Repeated infections can be fatal.

Since 2017, there have been few cases of Zika recorded in the U.S., but the disease persists sporadically in Africa, the Americas and Asia. The virus’ biggest health concern is for pregnant women because contracting Zika can increase risks for serious congenital birth defects.

While people in Mexico and Uganda may benefit from this research, Florida’s location as a worldwide travel destination adds to the growing need for solutions. U.S. dengue cases are on the rise and have been reported in Florida, California, Texas and Hawaii. Most are related to travel. Dengue is also prevalent in Puerto Rico.

“The threat to the U.S. is growing over time. … We want to be the leaders at looking at these viruses.â€� — James Earnest, Â鶹ӳ»­´«Ã½ Assistant Professor

“With more favorable temperatures and with people traveling around the globe these days, the threat to the U.S. is growing over time,â€� Earnest says. “I think, especially here in Florida, the potential for these mosquitoes to live in these areas and start transmitting these diseases in the very near future is high. Â鶹ӳ»­´«Ã½ recognizes that this is an important avenue of research for this region, and so we want to be the leaders at looking at these viruses.â€�

How the Â鶹ӳ»­´«Ã½Â Research Works

Earnest’s lab is focused on how the immune system responds to mosquito-borne viruses. Before arriving at Â鶹ӳ»­´«Ã½ in 2024, he tracked dengue via longitudinal sampling in Mexico’s Yucatan Peninsula.

Earnest is collaborating with the Uganda Virus Research Institute (UVRI) through a five-year $970,813 subcontract, part of a larger grant awarded to UVRI from Wellcome, a London-based charitable organization that supports science to solve urgent health challenges. The project aims to study immune system and antibody responses to dengue and Zika in large cohorts of people in Uganda and in Mexico.

Â鶹ӳ»­´«Ã½ will also collaborate with Emory University on a $578,157 grant from the National Institutes of Health, with Earnest subcontracted to Emory to study whether combining two current dengue inoculations used in Brazil gives humans better protection against repeat infections.

“It’s important that we understand what good and bad immune responses look like to these viruses.â€� — James Earnest, Â鶹ӳ»­´«Ã½ Assistant Professor

“It’s important that we understand what good and bad immune responses look like to these viruses,â€� Earnest says. “When we know those factors, then we can try to steer people in the right direction so that their antibodies will protect them from disease.â€�

Earnest will coordinate with teams in other countries to regularly collect blood samples and measure antibody production to get a comprehensive look at how different people’s bodies react to dengue and Zika over time. The samples will be collected and processed in Mexico and Uganda, and Earnest will analyze the results in his lab.

“I think what’s unique about this work is that we’re following people over time and not necessarily just when they get sick,â€� Earnest says.

His research focuses on B cells, which are white blood cells that make antibodies and help the body remember how to fight infections. By tracking how people’s B cells change over time, his team aims to understand how immune responses differ across regions.

In a related project with Emory, the lab will identify the most effective memory B cells and antibodies induced by two existing methods of inoculation for dengue, then test whether combining those methods in Brazilian trial participants produces a stronger immune response.

Students Aim to Save Lives Through Lab Work

With this new research, Earnest’s lab has welcomed two new Â鶹ӳ»­´«Ã½Â students who have personal experience with dengue and Zika.

Maiesha Mahmood, a second-year biotechnology master’s student, is from Bangladesh, where the threat of dengue looms.

“I have been around dengue a lot growing up,â€� Mahmood says. “I know people who have been in hospital with severe forms of dengue, and people who’ve passed away suddenly. People become scared of mosquitos and dengue.â€�

She says she hopes Â鶹ӳ»­´«Ã½â€™s research will someday save lives.

“Back in Bangladesh, we don’t really have a lot of facilities that can support virology research,â€� she says. “It was a huge opportunity to be able to come here and be able to work with Dr. Earnest. I want to continue looking into these kinds of viruses and find a way to help people who keep suffering from these diseases.â€�

µþ°ù³Ü²Ô´ÇÌý±Ê¾±²Ô³ó±ð¾±°ù´ÇÌý’25, a first-year Ph.D. candidate, joined Earnest’s lab to further his education and hopes research will help people close to him.

“My family is from Brazil and so Zika was a very big thing for them,â€� says Pinheiro, who earned his bachelor’s degree in biotechnology “It’s great to work on something that you can feel will impact the community that you’re a part of.â€�

Researcher Credentials:

Earnest joined Â鶹ӳ»­´«Ã½â€™s College of Medicine as an assistant professor in 2024. He earned his doctorate in microbiology and immunology from Loyola University Chicago in 2017. He performed postdoctoral research at Washington University in St. Louis studying antibody responses to mosquito-borne viruses and Emory University where he managed clinical field trials in Latin America.

Funding and Disclosure:

Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number U01AI186860. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.