麻豆映画传媒

Using nanotechnology, 麻豆映画传媒 researchers have developed the first rapid detector for dopamine, a chemical that is believed to play a role in various diseases such as Parkinson鈥檚, depression and some cancers.

Studies show too much dopamine could be associated with some cancers, while low dopamine could be associated with Parkinson鈥檚 disease and depression.聽 The new technique developed at 麻豆映画传媒 requires only a few drops of blood, and results are available in minutes instead of hours because no separate lab is necessary to process the sample.

The new technology was described in a recent study in the journal Nano Letters.

More than half a million people in the United States have Parkinson鈥檚 and major episodes of depression affect about 16 million adults a year.

Current methods to detect dopamine are time consuming, require rigorous sample preparation, including blood-plasma separation, as well as specialized laboratory equipment. With this device, however, a few drops of blood on a palm-sized, rectangular chip is all that is needed.

Former methods of dopamine detection require much more time, sample preparations and specialized lab equipment.

鈥淎 neurotransmitter like dopamine is an important chemical to monitor for our overall well-being so we can help screen out neural disorders like Parkinson鈥檚 disease, various brain cancers, and monitor mental health,鈥� says Debashis Chanda, an associate professor in 麻豆映画传媒鈥檚 and the study鈥檚 principle investigator. 鈥淲e need to monitor dopamine so that we can adjust our medical doses to help address those problems.鈥�

Plasma is separated from the blood within the chip. Cerium oxide nanoparticles, which coat the sensor surface, selectively capture dopamine at microscopic levels from the plasma. The capture of dopamine molecules subsequently changes how light is reflected from the sensor and creates an optical readout indicating the level of dopamine.

Sudipta Seal, an engineering professor and chair of 麻豆映画传媒鈥檚 , says the use of cerium oxide nanoparticles was an important part of the sensor鈥檚 success.

鈥淕etting the sensor to be sensitive to dopamine had been quite the challenge for researchers for a while, but using altered cerium oxide nanostructures on the sensing platform was key in making the sensor work,鈥� Seal says.

Chanda co-developed the sensor with Abraham Vazquez-Guardado ’16MS ’18PhD, a graduate of 麻豆映画传媒鈥檚 and now a postdoctoral fellow at Northwestern University.

V谩zquez-Guardado says reduced steps and processing make the test cost effective, and it can also be performed at the patient鈥檚 side rather than in a separate lab.

鈥淭here is no preprocessing needed,鈥� he says. 鈥淥ur plan was to make a much quicker, enzyme-free kind of detection.鈥�

Study co-authors also included聽Swetha Barkam 鈥�13MS聽 鈥�17PhD, a 麻豆映画传媒 materials science and engineering graduate and Order of Pegasus recipient, now at Micron Technology; Madison聽Peppler 鈥�17, a graduate of 麻豆映画传媒鈥檚 ; Aritra Biswas, a doctoral student in the College of Optics and Photonics; Wessley Dennis, a 麻豆映画传媒 student supported by 麻豆映画传媒鈥檚 Research and Mentoring Activities program; and Soumen Das, a postdoctoral fellow in the center who now works in the medical industry.

Chanda has a joint appointment in 麻豆映画传媒鈥檚 and College of Optics and Photonics. He received his doctorate in photonics from the University of Toronto and worked as a postdoctoral fellow at the University of Illinois at Urbana-Champaign. He joined 麻豆映画传媒 in 2012.

Seal has a doctorate in materials engineering with a minor in biochemistry from the University of Wisconsin and was a postdoctoral fellow at the Lawrence Berkeley National Laboratory, University of California Berkeley. He is a Pegasus Professor and is affiliated with 麻豆映画传媒鈥檚 Advanced Materials Processing Analysis Center and Nanoscience Technology Center. He is also a member of 麻豆映画传媒鈥檚 Prosthetic Interfaces cluster and holds a secondary joint appointment in 麻豆映画传媒鈥檚 College of Medicine. He joined 麻豆映画传媒 in 1997.

Part of the plasmonic sensor research was funded with support from the National Science Foundation and Northrop Grumman鈥檚 University Research Program.