{"id":109211,"date":"2020-05-06T12:38:12","date_gmt":"2020-05-06T16:38:12","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=109211"},"modified":"2020-05-06T12:38:12","modified_gmt":"2020-05-06T16:38:12","slug":"ucf-developed-cancer-fighting-nanoparticle-heads-to-clinical-trials","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/ucf-developed-cancer-fighting-nanoparticle-heads-to-clinical-trials\/","title":{"rendered":"Â鶹ӳ»­´«Ã½-Developed Cancer-Fighting Nanoparticle Heads to Clinical Trials"},"content":{"rendered":"<p>A cell-based cancer immunotherapy that utilizes a nanoparticle developed at Â鶹ӳ»­´«Ã½ to stimulate a patient\u2019s natural cancer-killing cells has just received the green light to proceed directly into a Phase II clinical trial.<\/p>\n<p>College of Medicine Associate Professor Alicja Copik and her team developed the technique in 2016 and then co-founded the company CytoSen to take the concept to market. <a href=\"https:\/\/www.ucf.edu\/news\/ucf-business-incubator-company-acquired-in-nearly-70-million-deal\/\">In 2019, the company was acquired by Netherlands-based bio-pharmaceutical firm Kiadis Pharma<\/a>, which saw the potential to develop new treatment options for cancer patients.<\/p>\n<p>Today, Kiadis Pharma, announced it received approval from the U.S. Food and Drug Administration to start its NK-REALM Phase II clinical trial. It had submitted the request to develop K-NK002, as an adjunctive therapy to use with people receiving hematopoietic stem cell transplantation to fight blood cancers. The goal would be to add it to the standard care delivered to these patients to reduce the rate in which the cancers come back.<\/p>\n<p>\u201cIt takes years to make a discovery that doesn\u2019t get a lot of attention at the time, but later it can make a huge difference,\u201d Copik says. \u201cI\u2019m so happy to see this moving forward with hopes it will soon make a positive impact on cancer patients. That\u2019s what it is all about, giving patients a fighting chance of cancer survival.\u201d<\/p>\n<p><a href=\"https:\/\/www.ucf.edu\/news\/natural-killer-cells-may-open-lifesaving-cancer-treatments-patients\/\">Copik, a native of Poland, arrived in the United States 22 years ago. After completing her doctorate and post-doctoral fellowships, she began studying natural killer cells, and then moved to Â鶹ӳ»­´«Ã½<\/a>.<\/p>\n<p>Natural killer (NK) cells are part of the body\u2019s defense system and act as an army to protect us from invaders such as viruses and infections. Copik discovered a way to make NK cells even more powerful \u2013 by stimulating them with nanoparticles that multiply them and heighten their killing ability.<\/p>\n<p>Kiadis Pharma\u2019s study will evaluate K-NK002 produced using Kiadis\u2019 proprietary PM21 technology platform licensed from Â鶹ӳ»­´«Ã½. This technology enables high dose, low cost, scalable and industrial production of NK-cell therapy without the risk of residual tumor cells in the final product. This is the first human trial using drug produced with Kiadis\u2019 PM21 technology, according to the company\u2019s press release. The study will enroll 64 patients at leading transplant centers in the U.S.<\/p>\n<p>\u201cThis is a great example of successful technology transfer of academic science to commercialization for the benefit of patients,\u201d says Svetlana Shtrom, director of Â鶹ӳ»­´«Ã½\u2019s Technology Transfer Office. \u201cResearchers make discoveries. We protect this valuable intellectual property. They either spin out a company and take it to market or we license the innovation to a commercial partner who can take it to market, to where it is needed to make a difference. That\u2019s the powerful role of universities working in partnership with businesses. That\u2019s how the technology-transfer ecosystem works to benefit our communities.\u201d<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alicja Copik discovered a way to make natural killer cells more powerful \u2013 by stimulating them with nanoparticles that enhance their cancer killing ability.<\/p>\n","protected":false},"author":16,"featured_media":109212,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,12,23],"tags":[653,979,14916,20720],"tu_author":[],"class_list":["post-109211","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-health","category-research","tag-burnett-school-of-biomedical-sciences","tag-college-of-medicine","tag-research","tag-technology-transfer-office"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Â鶹ӳ»­´«Ã½-Developed Cancer-Fighting Nanoparticle Heads to Clinical Trials | Â鶹ӳ»­´«Ã½ News<\/title>\n<meta name=\"description\" content=\"Alicja Copik 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