{"id":115176,"date":"2020-10-29T12:42:08","date_gmt":"2020-10-29T16:42:08","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=115176"},"modified":"2020-10-29T12:42:08","modified_gmt":"2020-10-29T16:42:08","slug":"ucf-researchers-natural-killer-cell-therapy-in-trials-for-treating-covid-19","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/ucf-researchers-natural-killer-cell-therapy-in-trials-for-treating-covid-19\/","title":{"rendered":"Â鶹ӳ»­´«Ã½ Researcher’s Natural Killer Cell Therapy In Trials for Treating COVID-19"},"content":{"rendered":"

An immunity-boosting technology developed by the College of Medicine is being tested as a potential weapon in the fight against COVID-19.<\/p>\n

Â鶹ӳ»­´«Ã½ cancer researcher Alicja Copik created the therapy that stimulates the body\u2019s natural killer (NK) cells with nanoparticles to increase their numbers and killing ability.\u00a0 Kiadis Pharma, one of the world\u2019s largest pharmaceutical companies, has licensed the technology and has it in clinical trials as a therapy for cancer. Now, with $9.5 million in funding from the Department of Defense and the Advanced Regenerative Manufacturing Institute\u2019s (ARMI) BioFabUSA program \u2014 which specializes in tissue engineering \u2014 Kiadis has begun clinical trials using NK cell therapy as a potential treatment for COVID-19 patients with weakened immune systems. The study will also see if the therapy protects high-risk patients against respiratory infections like influenza, either alone or in combination with vaccines and antibodies.<\/p>\n

\u201cWe\u2019ve lost more than 200,000 Americans from this terrible disease and so there is a great need to develop innovative medicines,” says Robert Igarashi, Kiadis Pharma\u2019s vice president of discovery and preclinical development and a former Â鶹ӳ»­´«Ã½ College of Medicine<\/a> faculty member. \u00a0\u201cWe know the body\u2019s natural killer cells surveil and suppress the virally compromised cells, so then we considered the potential of our NK cells as a possible therapeutic for COVID-19. And in our current situation, nationally and internationally, what better time could there be to apply this because there are so many people in need of innovative medicines to fight this pandemic.\u201d<\/p>\n

\u201cWe\u2019ve lost more than 200,000 Americans from this terrible disease and so there is a great need to develop innovative medicines.\u201d \u00a0– Robert Igarashi, Kiadis Pharma\u2019s vice president of discovery and preclinical development<\/p><\/blockquote>\n

\u201cThe NK cells are like the immune system\u2019s assassins,\u201d she says. \u201cWith our technology, we supercharge them with nanoparticles to not only increase their numbers but we make them deploy with bigger and heavier guns to better target and kill the bad guys which are invaders like viruses and tumor cells.\u201d<\/p>\n

Igarashi was a part of Copik\u2019s team of researchers who developed the NK cell technology in 2016. The researchers later co-founded the company CytoSen to take the concept to market.\u00a0In 2019, CytoSen was acquired by Netherlands-based Kiadis Pharma, which is now in clinical trials and hopes to see if the amplified NK cells have the ability to enhance a patient\u2019s antiviral immunity against COVID-19 and other viruses that could cause pandemics.<\/p>\n

Igarashi explains the vast majority of COVID-19 patients have lymphocytopenia, or a shortage of lymphocytes \u2014 a type of white blood cell that helps protect the body from infection. The severity of the COVID-19 infection has been correlated to a reduction in the number of NK cells, a type of lymphocytes, in the body. The clinical trials are determining if injecting energized NK cells into ill patients can help them fight COVID-19.<\/p>\n

Kiadis Pharma is working in partnership with the Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital in Columbus, Ohio. That institute received approval for an Investigational New Drug from the U.S. Food and Drug Administration to study the treatment of viral infections like COVID-19 with the NK cells therapeutic. Igarashi says the potential drug therapy is currently in phase one of clinical trials and could take several years before the drug is approved.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

The study will also see if the therapy, which was created by Alicja Copik, protects high-risk patients against respiratory infections like influenza.<\/p>\n","protected":false},"author":57,"featured_media":115181,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12],"tags":[15972,979,18250,2270],"tu_author":[],"class_list":["post-115176","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-alicja-copik","tag-college-of-medicine","tag-coronavirus","tag-impact"],"yoast_head":"\nÂ鶹ӳ»­´«Ã½ Researcher's Natural Killer Cell Therapy In Trials for Treating COVID-19<\/title>\n<meta name=\"description\" content=\"The study will also see if the therapy, which was created by Alicja Copik, protects high-risk patients against respiratory 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