{"id":129402,"date":"2022-06-29T10:46:46","date_gmt":"2022-06-29T14:46:46","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/129402///news/wp-json/wp/v2/posts/129402//www.ucf.edu/news/wp-json/wp/v2/posts/129402//news/news/wp-json/wp/v2/posts/129402//?p=129402"},"modified":"2023-01-09T12:01:24","modified_gmt":"2023-01-09T17:01:24","slug":"ucf-researchers-develop-liquid-biopsy-technique-to-help-detect-cancer-in-blood","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/129402///news/wp-json/wp/v2/posts/129402//www.ucf.edu/news/wp-json/wp/v2/posts/129402//news/news/wp-json/wp/v2/posts/129402//ucf-researchers-develop-liquid-biopsy-technique-to-help-detect-cancer-in-blood/news/wp-json/wp/v2/posts/129402//","title":{"rendered":"Â鶹ӳ»­´«Ã½ Researchers Develop Liquid Biopsy Technique to Help Detect Cancer in Blood"},"content":{"rendered":"<p>College of Medicine researchers have found a new way to track metastatic cancer cells in the body, which in the future could help identify cancer earlier and give patients more treatment options.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>In the latest issue of&nbsp;<em>PLOS ONE</news/wp-json/wp/v2/posts/129402//em>, Professor Annette Khaled/news/wp-json/wp/v2/posts/129402/u2019s research lab reported using a protein complex called a chaperonin as a new marker for cancer cells in blood /news/wp-json/wp/v2/posts/129402/u2014 that provides a clearer indication of spreading cancer. By using the new marker, Â鶹ӳ»­´«Ã½ scientists were able to detect more cancer cells in the blood, a procedure called liquid biopsy, which could help patients suffering from breast and lung cancers better monitor their disease.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>Cancer cells need a lot of proteins to survive and travel through the body. The chaperonin complex lets proteins fold into functional, three-dimensional shapes. Without the complex, important proteins needed by cancer cells can/news/wp-json/wp/v2/posts/129402/u2019t form. All cells contain the chaperonin complex. But cancer cells have significantly higher levels because as Khaled says, /news/wp-json/wp/v2/posts/129402/u201ccancer cells are hungry for protein./news/wp-json/wp/v2/posts/129402/u201d</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>In the past few years, Khaled identified the chaperonin complex as a significant indicator of a cancer/news/wp-json/wp/v2/posts/129402/u2019s severity and has developed nanoparticle-based therapies to seek out the chaperonin complex in cancer cells and destroy it. Without this protein-folding mechanism, cancer cells starve and die.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>/news/wp-json/wp/v2/posts/129402/u201cThe more chaperonin complex, the more advanced the cancer,/news/wp-json/wp/v2/posts/129402/u201d Khaled says. /news/wp-json/wp/v2/posts/129402/u201cBy using the chaperonin complex to detect cancer cells in blood, we get a warning that the cancer may be spreading. Using the chaperonin complex to detect cancer cells in blood is a unique solution for a non-invasive diagnosis./news/wp-json/wp/v2/posts/129402/u201d</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<figure id=/news/wp-json/wp/v2/posts/129402/"attachment_129404/news/wp-json/wp/v2/posts/129402/" style=/news/wp-json/wp/v2/posts/129402/"max-width: 297px;/news/wp-json/wp/v2/posts/129402/" class=/news/wp-json/wp/v2/posts/129402/"figure float-left/news/wp-json/wp/v2/posts/129402/"><noscript><img decoding=/news/wp-json/wp/v2/posts/129402/"async/news/wp-json/wp/v2/posts/129402/" width=/news/wp-json/wp/v2/posts/129402/"297/news/wp-json/wp/v2/posts/129402/" height=/news/wp-json/wp/v2/posts/129402/"300/news/wp-json/wp/v2/posts/129402/" class=/news/wp-json/wp/v2/posts/129402/"figure-img img-fluid w-100 wp-image-129404 size-medium/news/wp-json/wp/v2/posts/129402/" 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https:/news/wp-json/wp/v2/posts/129402///news/wp-json/wp/v2/posts/129402//www.ucf.edu/news/wp-json/wp/v2/posts/129402//wp-content/news/wp-json/wp/v2/posts/129402//blogs.dir/news/wp-json/wp/v2/posts/129402//20/news/wp-json/wp/v2/posts/129402//files/news/wp-json/wp/v2/posts/129402//2022/news/wp-json/wp/v2/posts/129402//06/news/wp-json/wp/v2/posts/129402//Annette-Khaled-357x360.jpeg 357w, https:/news/wp-json/wp/v2/posts/129402///news/wp-json/wp/v2/posts/129402//www.ucf.edu/news/wp-json/wp/v2/posts/129402//wp-content/news/wp-json/wp/v2/posts/129402//blogs.dir/news/wp-json/wp/v2/posts/129402//20/news/wp-json/wp/v2/posts/129402//files/news/wp-json/wp/v2/posts/129402//2022/news/wp-json/wp/v2/posts/129402//06/news/wp-json/wp/v2/posts/129402//Annette-Khaled.jpeg 1523w/news/wp-json/wp/v2/posts/129402/" data-src=/news/wp-json/wp/v2/posts/129402/"https:/news/wp-json/wp/v2/posts/129402///news/wp-json/wp/v2/posts/129402//www.ucf.edu/news/wp-json/wp/v2/posts/129402//news/news/wp-json/wp/v2/posts/129402//wp-content/news/wp-json/wp/v2/posts/129402//blogs.dir/news/wp-json/wp/v2/posts/129402//20/news/wp-json/wp/v2/posts/129402//files/news/wp-json/wp/v2/posts/129402//2022/news/wp-json/wp/v2/posts/129402//06/news/wp-json/wp/v2/posts/129402//Annette-Khaled-297x300.jpeg/news/wp-json/wp/v2/posts/129402/"><figcaption class=/news/wp-json/wp/v2/posts/129402/"figure-caption/news/wp-json/wp/v2/posts/129402/">Professor Annette Khaled is head of the College of Medicine/news/wp-json/wp/v2/posts/129402/u2019s cancer research division and assistant dean of faculty affairs.</news/wp-json/wp/v2/posts/129402//figcaption></news/wp-json/wp/v2/posts/129402//figure>/news/wp-json/wp/v2/posts/129402/n<p>Markers to identify cancer cells in blood are commonly based on epithelial features in cells that line surfaces of the body from which cancers arise. But such markers to detect cancer cells in blood are fairly /news/wp-json/wp/v2/posts/129402/u201cgeneric and provide little information about the cancer itself,/news/wp-json/wp/v2/posts/129402/u201d&nbsp;Khaled says. Cancer cells that are shed into blood can come from any part of the tumor and don/news/wp-json/wp/v2/posts/129402/u2019t survive past a few hours.&nbsp; So, using a marker like the chaperonin complex that identifies dangerous cancer cells circulating in blood could alert doctors that a patient is relapsing or not responding to treatments.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>Khaled is head of the College of Medicine/news/wp-json/wp/v2/posts/129402/u2019s Division of Cancer Research. Her study began by using blood and tissues from metastatic breast cancer patients being treated at Orlando Health/news/wp-json/wp/v2/posts/129402/u2019s UF Cancer Center to test if the chaperonin complex was better than traditional markers to identify cancer cells in blood. Then with blood from lung cancer patients, she validated this idea and found that using the chaperonin complex detected more lung cancer cells compared to standard methods for liquid biopsy.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>The Â鶹ӳ»­´«Ã½ research team used the FDA-approved CELLSEARCH System, that was purchased thanks to a generous donation from the Catherine McCaw-Engelman and Family Cancer Research Collaborative Fund, set up to honor a Winter Park, Florida, woman who died of colon cancer that was not detected until it had spread. The equipment can isolate, photograph and count cancer cells from a single tube of blood and was adapted for detection of the chaperonin complex in blood cells.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>The findings come as a result of $1.5 million Khaled has received over the past seven years from Orlando/news/wp-json/wp/v2/posts/129402/u2019s Cure Bowl, the only NCAA college football bowl game created specifically to support a cause /news/wp-json/wp/v2/posts/129402/u2014 cancer research. Khaled/news/wp-json/wp/v2/posts/129402/u2019s latest Cure Bowl grant of $60,000 will be presented to her at the game in December.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n<p>Khaled joined Â鶹ӳ»­´«Ã½ in 2002 after receiving her Ph.D. from the University of Florida and doing post graduate training at the National Cancer Institute (NCI). A tenured professor, she has been funded by multiple RO1 grants from the National Institutes of Health, the Breast Cancer Research Foundation, and most recently the Florida Department of Health. She has published more than 100 manuscripts and abstracts and presented her research at numerous national and international scientific meetings. &nbsp;She has been recognized with research, leadership and teaching awards including the NCI CURE Lifetime Achievement Award. In addition to her research responsibilities, she teaches molecular immunology to Â鶹ӳ»­´«Ã½ graduate students and serves as the College of Medicine/news/wp-json/wp/v2/posts/129402/u2019s assistant dean for Faculty Affairs.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n","protected":false},"excerpt":{"rendered":"<p>The method could detect metastatic cancer, which spreads throughout the body, earlier.</news/wp-json/wp/v2/posts/129402//p>/news/wp-json/wp/v2/posts/129402/n","protected":false},"author":57,"featured_media":129403,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12],"tags":[14946,979,22543,14916],"tu_author":[],"class_list":["post-129402","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-annette-khaled","tag-college-of-medicine","tag-healthcare","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.5) - https:/news/wp-json/wp/v2/posts/129402///news/wp-json/wp/v2/posts/129402//yoast.com/news/wp-json/wp/v2/posts/129402//product/news/wp-json/wp/v2/posts/129402//yoast-seo-premium-wordpress/news/wp-json/wp/v2/posts/129402// 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