{"id":152297,"date":"2026-04-13T08:54:33","date_gmt":"2026-04-13T12:54:33","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//www.ucf.edu/news/wp-json/wp/v2/posts/152297//news/news/wp-json/wp/v2/posts/152297//?p=152297"},"modified":"2026-04-10T11:54:57","modified_gmt":"2026-04-10T15:54:57","slug":"ucf-expert-plays-key-role-in-international-research-to-combat-dengue-fever-zika","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//www.ucf.edu/news/wp-json/wp/v2/posts/152297//news/news/wp-json/wp/v2/posts/152297//ucf-expert-plays-key-role-in-international-research-to-combat-dengue-fever-zika/news/wp-json/wp/v2/posts/152297//","title":{"rendered":"Â鶹ӳ»­´«Ã½ Expert Plays Key Role in International Research to Combat Dengue Fever, Zika"},"content":{"rendered":"<hr>/news/wp-json/wp/v2/posts/152297/n<p>Nearly half&nbsp;of the world/news/wp-json/wp/v2/posts/152297/u2019s citizens&nbsp;live in areas with a&nbsp;risk of catching dengue fever,&nbsp;according to&nbsp;the Centers for Disease Control and Prevention.&nbsp;As&nbsp;the mosquito-borne&nbsp;illness rapidly&nbsp;spreads, especially in the Americas and Caribbean, a&nbsp;<a href=/news/wp-json/wp/v2/posts/152297/"https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//med.ucf.edu/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297/">Â鶹ӳ»­´«Ã½ College of Medicine</news/wp-json/wp/v2/posts/152297//a>&nbsp;researcher is playing a crucial role in finding solutions.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>James&nbsp;Earnest, an assistant professor at the Burnett School of Biomedical Sciences, is&nbsp;leading&nbsp;two&nbsp;new&nbsp;<a href=/news/wp-json/wp/v2/posts/152297/"https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//www.ucf.edu/news/wp-json/wp/v2/posts/152297//research/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297/">research</news/wp-json/wp/v2/posts/152297//a> projects to examine how humans build an immune response to dengue and the Zika virus over time, in pursuit of creating better preventative measures.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<figure id=/news/wp-json/wp/v2/posts/152297/"attachment_152321/news/wp-json/wp/v2/posts/152297/" style=/news/wp-json/wp/v2/posts/152297/"max-width: 1200px;/news/wp-json/wp/v2/posts/152297/" class=/news/wp-json/wp/v2/posts/152297/"figure mx-auto d-block/news/wp-json/wp/v2/posts/152297/"><noscript><img decoding=/news/wp-json/wp/v2/posts/152297/"async/news/wp-json/wp/v2/posts/152297/" width=/news/wp-json/wp/v2/posts/152297/"1200/news/wp-json/wp/v2/posts/152297/" 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class=/news/wp-json/wp/v2/posts/152297/"figure-caption/news/wp-json/wp/v2/posts/152297/">From left to right: Â鶹ӳ»­´«Ã½ research associate Daniel Limonta,Â鶹ӳ»­´«Ã½ Assistant Professor James Earnest and biomedical sciences doctoral student Bruno Pinheiro /news/wp-json/wp/v2/posts/152297/u201925. (Photo by Eddy Duryea /news/wp-json/wp/v2/posts/152297/u201913/news/wp-json/wp/v2/posts/152297/u202f)</news/wp-json/wp/v2/posts/152297//figcaption></news/wp-json/wp/v2/posts/152297//figure>/news/wp-json/wp/v2/posts/152297/n<h2>Tackling a Global Problem</news/wp-json/wp/v2/posts/152297//h2>/news/wp-json/wp/v2/posts/152297/n<p>Both&nbsp;dengue and&nbsp;Zika&nbsp;are carried by the&nbsp;<em>Aedes aegypti</news/wp-json/wp/v2/posts/152297//em>&nbsp;mosquito,&nbsp;which has expanded&nbsp;its habitat from Africa to tropical,&nbsp;subtropical&nbsp;and even&nbsp;temperate&nbsp;areas worldwide.&nbsp;According to the World Health Organization, dengue infections in humans climbed&nbsp;from&nbsp;505,430 in 2000&nbsp;to&nbsp;14.6 million in 2024, an increase of more than 2,700%.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Dengue can be asymptomatic or cause severe pain, fatigue and high fever. Repeated infections can be fatal.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Since 2017, there have been few cases of&nbsp;Zika&nbsp;recorded in the U.S., but the disease persists sporadically in Africa, the Americas and Asia. The virus/news/wp-json/wp/v2/posts/152297/u2019 biggest health concern is&nbsp;for&nbsp;pregnant&nbsp;women because contracting&nbsp;Zika&nbsp;can increase risks for&nbsp;serious&nbsp;congenital birth defects.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>While people in Mexico and Uganda&nbsp;may&nbsp;benefit&nbsp;from this research,&nbsp;Florida/news/wp-json/wp/v2/posts/152297/u2019s location as a worldwide travel destination&nbsp;adds to&nbsp;the&nbsp;growing&nbsp;need for solutions.&nbsp;U.S.&nbsp;dengue&nbsp;cases&nbsp;are on the rise and&nbsp;have been reported in Florida, California,&nbsp;Texas&nbsp;and Hawaii. Most are related to travel.&nbsp;Dengue is also prevalent in&nbsp;Puerto Rico.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<blockquote><p>/news/wp-json/wp/v2/posts/152297/u201cThe threat to the U.S. is growing over time. &#8230; We want to be the leaders at looking at these viruses./news/wp-json/wp/v2/posts/152297/u201d /news/wp-json/wp/v2/posts/152297/u2014 James Earnest, Â鶹ӳ»­´«Ã½ Assistant Professor</news/wp-json/wp/v2/posts/152297//p></news/wp-json/wp/v2/posts/152297//blockquote>/news/wp-json/wp/v2/posts/152297/n<p>/news/wp-json/wp/v2/posts/152297/u201cWith more favorable temperatures and with people traveling around the globe these days, the threat to the U.S. is growing over time,/news/wp-json/wp/v2/posts/152297/u201d Earnest says. /news/wp-json/wp/v2/posts/152297/u201cI think, especially here in Florida, the potential for these mosquitoes to live in these areas and start transmitting these diseases in the very near future is high. 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https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//www.ucf.edu/news/wp-json/wp/v2/posts/152297//wp-content/news/wp-json/wp/v2/posts/152297//blogs.dir/news/wp-json/wp/v2/posts/152297//20/news/wp-json/wp/v2/posts/152297//files/news/wp-json/wp/v2/posts/152297//2026/news/wp-json/wp/v2/posts/152297//04/news/wp-json/wp/v2/posts/152297//Mexico-research-field-team-mosquito-360x240.jpg 360w/news/wp-json/wp/v2/posts/152297/" data-src=/news/wp-json/wp/v2/posts/152297/"https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//www.ucf.edu/news/wp-json/wp/v2/posts/152297//wp-content/news/wp-json/wp/v2/posts/152297//blogs.dir/news/wp-json/wp/v2/posts/152297//20/news/wp-json/wp/v2/posts/152297//files/news/wp-json/wp/v2/posts/152297//2026/news/wp-json/wp/v2/posts/152297//04/news/wp-json/wp/v2/posts/152297//Mexico-research-field-team-mosquito.jpg/news/wp-json/wp/v2/posts/152297/"><figcaption class=/news/wp-json/wp/v2/posts/152297/"figure-caption/news/wp-json/wp/v2/posts/152297/">Earnest&#8217;s research field team in Mexico collects samples. (Photo provided by James Earnest)</news/wp-json/wp/v2/posts/152297//figcaption></news/wp-json/wp/v2/posts/152297//figure>/news/wp-json/wp/v2/posts/152297/n<h2>How the&nbsp;Â鶹ӳ»­´«Ã½&nbsp;Research Works</news/wp-json/wp/v2/posts/152297//h2>/news/wp-json/wp/v2/posts/152297/n<p>Earnest/news/wp-json/wp/v2/posts/152297/u2019s lab is focused on how the immune system responds to mosquito-borne viruses. Before arriving at Â鶹ӳ»­´«Ã½ in 2024, he tracked dengue via longitudinal sampling in Mexico/news/wp-json/wp/v2/posts/152297/u2019s Yucatan Peninsula.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Earnest is collaborating with the Uganda Virus Research Institute (UVRI) through a five-year $970,813 subcontract, part of a larger grant awarded to UVRI from Wellcome, a London-based charitable organization that supports science to solve urgent health challenges. The project aims to study immune system and antibody responses to dengue and Zika in large cohorts of people in Uganda and in Mexico.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Â鶹ӳ»­´«Ã½ will also collaborate with Emory University on a&nbsp;$578,157&nbsp;grant from the National Institutes of Health, with Earnest subcontracted to Emory to study whether combining two current dengue inoculations used in Brazil gives humans better protection against repeat infections.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<blockquote><p>/news/wp-json/wp/v2/posts/152297/u201cIt&#8217;s important that we understand what good and bad immune responses look like to these viruses./news/wp-json/wp/v2/posts/152297/u201d /news/wp-json/wp/v2/posts/152297/u2014 James Earnest, Â鶹ӳ»­´«Ã½ Assistant Professor</news/wp-json/wp/v2/posts/152297//p></news/wp-json/wp/v2/posts/152297//blockquote>/news/wp-json/wp/v2/posts/152297/n<p>/news/wp-json/wp/v2/posts/152297/u201cIt&#8217;s&nbsp;important&nbsp;that we understand what good and bad immune responses look like to these viruses,/news/wp-json/wp/v2/posts/152297/u201d&nbsp;Earnest&nbsp;says. /news/wp-json/wp/v2/posts/152297/u201cWhen we know those factors, then&nbsp;we can try to steer people in&nbsp;the right&nbsp;direction so that their antibodies will protect them from&nbsp;disease./news/wp-json/wp/v2/posts/152297/u201d</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Earnest will coordinate with teams in other countries to regularly collect blood samples and measure antibody production to get a comprehensive look at how different people/news/wp-json/wp/v2/posts/152297/u2019s bodies react to dengue and Zika over time. The samples will be collected and processed in Mexico and Uganda, and Earnest will analyze the results in his lab.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>/news/wp-json/wp/v2/posts/152297/u201cI think what&#8217;s unique about&nbsp;this work is that we/news/wp-json/wp/v2/posts/152297/u2019re&nbsp;following people over time and not necessarily&nbsp;just&nbsp;when they get sick,/news/wp-json/wp/v2/posts/152297/u201d&nbsp;Earnest says.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>His research focuses on B cells, which are white blood cells that make antibodies and help the body remember how to fight infections. By tracking how&nbsp;people/news/wp-json/wp/v2/posts/152297/u2019s&nbsp;B cells change over time, his team aims to understand how immune responses differ across regions.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>In a related project with Emory, the lab will&nbsp;identify&nbsp;the most effective memory B cells and antibodies induced by two existing methods of inoculation for dengue, then test whether combining those methods in Brazilian trial participants produces a stronger immune response.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<h2>Students Aim to Save Lives Through Lab Work</news/wp-json/wp/v2/posts/152297//h2>/news/wp-json/wp/v2/posts/152297/n<p>With this new research,&nbsp;Earnest/news/wp-json/wp/v2/posts/152297/u2019s lab has welcomed&nbsp;two new Â鶹ӳ»­´«Ã½&nbsp;students&nbsp;who have&nbsp;personal&nbsp;experience&nbsp;with&nbsp;dengue and&nbsp;Zika.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Maiesha&nbsp;Mahmood, a&nbsp;second-year&nbsp;<a href=/news/wp-json/wp/v2/posts/152297/"https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//www.ucf.edu/news/wp-json/wp/v2/posts/152297//degree/news/wp-json/wp/v2/posts/152297//biotechnology-ms/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297/">biotechnology</news/wp-json/wp/v2/posts/152297//a>&nbsp;master/news/wp-json/wp/v2/posts/152297/u2019s student,&nbsp;is from Bangladesh, where the threat of dengue looms.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>/news/wp-json/wp/v2/posts/152297/u201cI have been around dengue a lot growing up,/news/wp-json/wp/v2/posts/152297/u201d Mahmood&nbsp;says.&nbsp;/news/wp-json/wp/v2/posts/152297/u201cI know people who have been in hospital&nbsp;with&nbsp;severe forms&nbsp;of dengue, and&nbsp;people&nbsp;who&#8217;ve&nbsp;passed away&nbsp;suddenly.&nbsp;People become scared of mosquitos and dengue./news/wp-json/wp/v2/posts/152297/u201d</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>She&nbsp;says she&nbsp;hopes&nbsp;Â鶹ӳ»­´«Ã½/news/wp-json/wp/v2/posts/152297/u2019s research will someday save lives.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>/news/wp-json/wp/v2/posts/152297/u201cBack in Bangladesh,&nbsp;we don&#8217;t really have a lot of facilities that can support virology research,/news/wp-json/wp/v2/posts/152297/u201d&nbsp;she says. /news/wp-json/wp/v2/posts/152297/u201cIt was&nbsp;a huge opportunity to be able to come here and be able to work&nbsp;with Dr. Earnest.&nbsp;I want to continue looking into these kinds of&nbsp;viruses&nbsp;and&nbsp;find&nbsp;a way to help people who keep suffering from&nbsp;these&nbsp;diseases./news/wp-json/wp/v2/posts/152297/u201d</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p><strong>Bruno&nbsp;Pinheiro&nbsp;/news/wp-json/wp/v2/posts/152297/u201925</news/wp-json/wp/v2/posts/152297//strong>, a first-year Ph.D. candidate,&nbsp;joined Earnest/news/wp-json/wp/v2/posts/152297/u2019s lab&nbsp;to further his education and hopes research will&nbsp;help people close to him.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>/news/wp-json/wp/v2/posts/152297/u201cMy family is from Brazil and so&nbsp;Zika&nbsp;was a very big thing for them,/news/wp-json/wp/v2/posts/152297/u201d says&nbsp;Pinheiro, who&nbsp;earned his bachelor/news/wp-json/wp/v2/posts/152297/u2019s degree in&nbsp;<a href=/news/wp-json/wp/v2/posts/152297/"https:/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297//www.ucf.edu/news/wp-json/wp/v2/posts/152297//degree/news/wp-json/wp/v2/posts/152297//biotechnology-bs/news/wp-json/wp/v2/posts/152297///news/wp-json/wp/v2/posts/152297/">biotechnology</news/wp-json/wp/v2/posts/152297//a>&nbsp;/news/wp-json/wp/v2/posts/152297/u201cIt/news/wp-json/wp/v2/posts/152297/u2019s great to work on something that you can feel will impact the community that you&#8217;re a part of./news/wp-json/wp/v2/posts/152297/u201d</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p><strong>Researcher Credentials:</news/wp-json/wp/v2/posts/152297//strong></news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Earnest joined Â鶹ӳ»­´«Ã½/news/wp-json/wp/v2/posts/152297/u2019s College of Medicine as&nbsp;an assistant professor&nbsp;in 2024. He&nbsp;earned&nbsp;his doctorate in&nbsp;microbiology and&nbsp;immunology from Loyola University Chicago in 2017. He performed postdoctoral research at Washington University in St. Louis studying antibody responses to mosquito-borne viruses and Emory University where he managed clinical field trials in Latin America.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p><strong>Funding&nbsp;and Disclosure:</news/wp-json/wp/v2/posts/152297//strong></news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n<p>Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number U01AI186860. The content is solely the responsibility of the authors and does not necessarily&nbsp;represent&nbsp;the official views of the National Institutes of Health.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n","protected":false},"excerpt":{"rendered":"<p>As a mosquito-borne virus expert, Â鶹ӳ»­´«Ã½ Assistant Professor James Earnest is leveraging his knowledge to lead two research projects studying immune responses to the dengue and Zika viruses.</news/wp-json/wp/v2/posts/152297//p>/news/wp-json/wp/v2/posts/152297/n","protected":false},"author":98,"featured_media":152319,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12,17,23],"tags":[12892,653,979,54929,14916],"tu_author":[],"class_list":["post-152297","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-medicine","category-research","tag-biotechnology","tag-burnett-school-of-biomedical-sciences","tag-college-of-medicine","tag-james-earnest","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - 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