{"id":153496,"date":"2026-06-01T09:19:55","date_gmt":"2026-06-01T13:19:55","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//news/news/wp-json/wp/v2/posts/153496//?p=153496"},"modified":"2026-06-01T09:19:55","modified_gmt":"2026-06-01T13:19:55","slug":"ucf-scientist-leads-research-to-break-through-harmful-bacterial-fortresses","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//news/news/wp-json/wp/v2/posts/153496//ucf-scientist-leads-research-to-break-through-harmful-bacterial-fortresses/news/wp-json/wp/v2/posts/153496//","title":{"rendered":"Â鶹ӳ»­´«Ã½ Scientist Leads Research to Break Through Harmful Bacterial /news/wp-json/wp/v2/posts/153496/u201cFortresses/news/wp-json/wp/v2/posts/153496/u201d"},"content":{"rendered":"<p>College of Medicine&nbsp;Assistant Professor&nbsp;Renee Fleeman&nbsp;<a href=/news/wp-json/wp/v2/posts/153496/"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//news/news/wp-json/wp/v2/posts/153496//medical-school-scientist-creates-therapy-to-kill-hypervirulent-bacteria/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496/">continues&nbsp;to refine a powerful&nbsp;therapy</news/wp-json/wp/v2/posts/153496//a> for drug-resistant bacteria that pierces the gooey coating that anchors and protects such germs from the drugs we take to kill them.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>Her&nbsp;<a href=/news/wp-json/wp/v2/posts/153496/"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//research/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496/">research</news/wp-json/wp/v2/posts/153496//a>, backed by a five-year $813,130 National Institute of Allergy and Infectious Diseases grant, found that an antimicrobial peptide naturally found in cows weakens the biofilm defenses of <em>Klebsiella pneumoniae </news/wp-json/wp/v2/posts/153496//em>bacteria and destroys it.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>Now in their fourth year of research, Fleeman and her lab have discovered exactly how the peptide works in findings published in <em>PLOS Pathogens</news/wp-json/wp/v2/posts/153496//em>.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>/news/wp-json/wp/v2/posts/153496/u201cOur research is very advantageous for healthcare because about 80% of bacterial infections being treated in the clinic are bacteria living in a biofilm state, which makes them resistant to virtually every antibiotic available,/news/wp-json/wp/v2/posts/153496/u201d she says.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>The results&nbsp;represent&nbsp;a critical step to potentially applying this peptide as a therapy and eventually treating patients,&nbsp;as the findings&nbsp;show they can and kill biofilm-embedded bacteria in animal models.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<figure id=/news/wp-json/wp/v2/posts/153496/"attachment_153498/news/wp-json/wp/v2/posts/153496/" style=/news/wp-json/wp/v2/posts/153496/"max-width: 1200px;/news/wp-json/wp/v2/posts/153496/" class=/news/wp-json/wp/v2/posts/153496/"figure mx-auto d-block/news/wp-json/wp/v2/posts/153496/"><noscript><img decoding=/news/wp-json/wp/v2/posts/153496/"async/news/wp-json/wp/v2/posts/153496/" width=/news/wp-json/wp/v2/posts/153496/"1200/news/wp-json/wp/v2/posts/153496/" height=/news/wp-json/wp/v2/posts/153496/"800/news/wp-json/wp/v2/posts/153496/" class=/news/wp-json/wp/v2/posts/153496/"figure-img size-full wp-image-153498 img-fluid/news/wp-json/wp/v2/posts/153496/" 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src=/news/wp-json/wp/v2/posts/153496/"data:image/news/wp-json/wp/v2/posts/153496//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/153496/" alt=/news/wp-json/wp/v2/posts/153496/"Man wearing black glasses and white lab coat holds up dish with jelly circles between his blue gloved hands/news/wp-json/wp/v2/posts/153496/" srcset=/news/wp-json/wp/v2/posts/153496/"data:image/news/wp-json/wp/v2/posts/153496//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w/news/wp-json/wp/v2/posts/153496/" sizes=/news/wp-json/wp/v2/posts/153496/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/153496/" data-srcset=/news/wp-json/wp/v2/posts/153496/"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Robert-Backman-lab-14.jpg 1200w, https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Robert-Backman-lab-14-300x200.jpg 300w, https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Robert-Backman-lab-14-768x512.jpg 768w, https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Robert-Backman-lab-14-600x400.jpg 600w, https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Robert-Backman-lab-14-360x240.jpg 360w/news/wp-json/wp/v2/posts/153496/" data-src=/news/wp-json/wp/v2/posts/153496/"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Robert-Backman-lab-14.jpg/news/wp-json/wp/v2/posts/153496/"><figcaption class=/news/wp-json/wp/v2/posts/153496/"figure-caption/news/wp-json/wp/v2/posts/153496/">Robert Beckman /news/wp-json/wp/v2/posts/153496/u201913 shows an isolated experiment that demonstrates how their peptide kills<em> K. pneumoniae</news/wp-json/wp/v2/posts/153496//em>, which is a critical step before testing in animal or human models.</news/wp-json/wp/v2/posts/153496//figcaption></news/wp-json/wp/v2/posts/153496//figure>/news/wp-json/wp/v2/posts/153496/n<h2>Parsing out the Peptide</news/wp-json/wp/v2/posts/153496//h2>/news/wp-json/wp/v2/posts/153496/n<p><em>K. pneumoniae</news/wp-json/wp/v2/posts/153496//em> is found in the intestines and is usually harmless, however, the bacterium develops resistance over a person/news/wp-json/wp/v2/posts/153496/u2019s lifetime as they are exposed to antibiotics. The bacteria also can spread from the intestine to other parts of the body in immunocompromised patients and those who have internal ruptures or exposure to contaminated medical devices. That exposure can lead to pneumonia, urinary tract or wound infections.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>/news/wp-json/wp/v2/posts/153496/u201cWhat happens is the bacteria&nbsp;infects&nbsp;the wound, proliferates, and then invades through the bloodstream&nbsp;where it travels&nbsp;to the liver, kidneys and spleen,/news/wp-json/wp/v2/posts/153496/u201d Fleeman&nbsp;says. /news/wp-json/wp/v2/posts/153496/u201cWe&nbsp;found&nbsp;our peptide&nbsp;was able to decrease the bacteria&nbsp;at the source while limiting&nbsp;the bacteria/news/wp-json/wp/v2/posts/153496/u2019s&nbsp;ability to move&nbsp;through the blood./news/wp-json/wp/v2/posts/153496/u201d</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>Fleeman and her lab/news/wp-json/wp/v2/posts/153496/u2019s most recent study found that the peptide triggers a dual stress response that tricks the bacteria to break out of their protective biofilm.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>They discovered the genetics of a specific protein in the bacterium when turned on in the germ causes it to break from its own protective biofilm. The peptide, in effect, damages the protection and then stresses the bacterium into shedding its protection, making the germ more sensitive to antibiotics and the body/news/wp-json/wp/v2/posts/153496/u2019s immune system.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>/news/wp-json/wp/v2/posts/153496/u201cBy&nbsp;hitting the membrane as well as protein synthesis at the same time, it&#8217;s&nbsp;a double punch that triggers a genetic&nbsp;change&nbsp;in the cell to make it think it needs to break out of&nbsp;the biofilm as a response to our peptide,/news/wp-json/wp/v2/posts/153496/u201d Fleeman&nbsp;says.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>The team says their sustained research aims to demonstrate that their peptide can work synergistically with existing antibiotics. They envision long-term applications could involve a topical cream that weakens the bacteria/news/wp-json/wp/v2/posts/153496/u2019s defenses and allows standard antibiotics to work more effectively.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>/news/wp-json/wp/v2/posts/153496/u201cWe/news/wp-json/wp/v2/posts/153496/u2019re moving our research&nbsp;forward&nbsp;and we/news/wp-json/wp/v2/posts/153496/u2019re very hopeful,/news/wp-json/wp/v2/posts/153496/u201d Fleeman&nbsp;says.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<figure id=/news/wp-json/wp/v2/posts/153496/"attachment_153499/news/wp-json/wp/v2/posts/153496/" style=/news/wp-json/wp/v2/posts/153496/"max-width: 1200px;/news/wp-json/wp/v2/posts/153496/" class=/news/wp-json/wp/v2/posts/153496/"figure mx-auto d-block/news/wp-json/wp/v2/posts/153496/"><noscript><img decoding=/news/wp-json/wp/v2/posts/153496/"async/news/wp-json/wp/v2/posts/153496/" 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src=/news/wp-json/wp/v2/posts/153496/"data:image/news/wp-json/wp/v2/posts/153496//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/153496/" alt=/news/wp-json/wp/v2/posts/153496/"Dr. Renee Fleeman stands with mixed group of six men and women, all in white lab coats, with shelves of lab equipment around them. /news/wp-json/wp/v2/posts/153496/" srcset=/news/wp-json/wp/v2/posts/153496/"data:image/news/wp-json/wp/v2/posts/153496//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w/news/wp-json/wp/v2/posts/153496/" sizes=/news/wp-json/wp/v2/posts/153496/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/153496/" data-srcset=/news/wp-json/wp/v2/posts/153496/"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Fleeman-and-lab-students.jpg 1200w, https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Fleeman-and-lab-students-300x200.jpg 300w, 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https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Fleeman-and-lab-students-360x240.jpg 360w/news/wp-json/wp/v2/posts/153496/" data-src=/news/wp-json/wp/v2/posts/153496/"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//wp-content/news/wp-json/wp/v2/posts/153496//blogs.dir/news/wp-json/wp/v2/posts/153496//20/news/wp-json/wp/v2/posts/153496//files/news/wp-json/wp/v2/posts/153496//2026/news/wp-json/wp/v2/posts/153496//05/news/wp-json/wp/v2/posts/153496//Fleeman-and-lab-students.jpg/news/wp-json/wp/v2/posts/153496/"><figcaption class=/news/wp-json/wp/v2/posts/153496/"figure-caption/news/wp-json/wp/v2/posts/153496/">Renee Fleeman/news/wp-json/wp/v2/posts/153496/u2019s lab group is comprised of students who, under Fleeman/news/wp-json/wp/v2/posts/153496/u2019s mentorship, gain valuable research experience. (Photo by Kadeem Stewart)</news/wp-json/wp/v2/posts/153496//figcaption></news/wp-json/wp/v2/posts/153496//figure>/news/wp-json/wp/v2/posts/153496/n<h2>Preparing for the Post-Antibiotic Era</news/wp-json/wp/v2/posts/153496//h2>/news/wp-json/wp/v2/posts/153496/n<p>The first author of this new work&nbsp;is&nbsp;<strong>Robert Beckman&nbsp;/news/wp-json/wp/v2/posts/153496/u201923</news/wp-json/wp/v2/posts/153496//strong>, who graduated&nbsp;from Â鶹ӳ»­´«Ã½&nbsp;with a&nbsp;<a href=/news/wp-json/wp/v2/posts/153496/"https:/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496//www.ucf.edu/news/wp-json/wp/v2/posts/153496//degree/news/wp-json/wp/v2/posts/153496//health-sciences-bs/news/wp-json/wp/v2/posts/153496///news/wp-json/wp/v2/posts/153496/">bachelor/news/wp-json/wp/v2/posts/153496/u2019s degree in health sciences</news/wp-json/wp/v2/posts/153496//a>,&nbsp;managed&nbsp;Fleeman/news/wp-json/wp/v2/posts/153496/u2019s lab&nbsp;and is now on his way to&nbsp;the University of Michigan&nbsp;for his Ph.D.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>His&nbsp;previous&nbsp;work as an EMT gave him firsthand exposure to&nbsp;infectious diseases and their impact on&nbsp;patients.&nbsp;He&nbsp;says&nbsp;helping to lead the study and&nbsp;working with&nbsp;Fleeman helped prepare him for a career in medical research.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>/news/wp-json/wp/v2/posts/153496/u201cI have developed a strong foundation in research and gained insight into the many components that define an effective scientist,/news/wp-json/wp/v2/posts/153496/u201d he&nbsp;says. /news/wp-json/wp/v2/posts/153496/u201cMy long-term goal is to remain in academia and eventually lead my own research lab.&nbsp;I plan to continue focusing on bacteriology, with a particular emphasis on pathogenic bacteria and drug discovery applications./news/wp-json/wp/v2/posts/153496/u201d</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p><strong>Funding and Disclosure:</news/wp-json/wp/v2/posts/153496//strong></news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n<p>Research reported in this publication was supported by the National Institute&nbsp;of Allergy&nbsp;and Infectious Diseases of the National Institutes of Health under Award Number R00AI163295. The content is solely the responsibility of the authors and does not necessarily&nbsp;represent&nbsp;the official views of the National Institutes of Health.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n","protected":false},"excerpt":{"rendered":"<p>Continuing/news/wp-json/wp/v2/posts/153496/u00a0her work/news/wp-json/wp/v2/posts/153496/u00a0with/news/wp-json/wp/v2/posts/153496/u00a0antibiotic-resistant/news/wp-json/wp/v2/posts/153496/u00a0bacteria, Renee Fleeman/news/wp-json/wp/v2/posts/153496/u00a0is/news/wp-json/wp/v2/posts/153496/u00a0understanding/news/wp-json/wp/v2/posts/153496/u00a0how/news/wp-json/wp/v2/posts/153496/u00a0a/news/wp-json/wp/v2/posts/153496/u00a0bioengineered/news/wp-json/wp/v2/posts/153496/u00a0peptide can/news/wp-json/wp/v2/posts/153496/u00a0curb severe infections for patients.</news/wp-json/wp/v2/posts/153496//p>/news/wp-json/wp/v2/posts/153496/n","protected":false},"author":98,"featured_media":153500,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12,17,23],"tags":[16873,979,5742,14916,202],"tu_author":[],"class_list":["post-153496","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-medicine","category-research","tag-college-of-health-professions-and-sciences","tag-college-of-medicine","tag-health-sciences","tag-research","tag-alumni"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.5) - 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College of Medicine Assistant Professor Renee Fleeman and her lab group work to understand how to fight some of the strongest and most harmful bacteria to humans. 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