{"id":155281,"date":"2026-09-23T10:00:59","date_gmt":"2026-09-23T14:00:59","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//news/news/wp-json/wp/v2/posts/155281//?p=155281"},"modified":"2026-09-16T15:22:09","modified_gmt":"2026-09-16T19:22:09","slug":"ucf-researcher-identifies-10-potential-treatments-for-rare-nerve-tumor-in-children","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//news/news/wp-json/wp/v2/posts/155281//ucf-researcher-identifies-10-potential-treatments-for-rare-nerve-tumor-in-children/news/wp-json/wp/v2/posts/155281//","title":{"rendered":"Â鶹ӳ»­´«Ã½ Researcher Identifies 10 Potential Treatments for Rare Nerve Tumor in Children"},"content":{"rendered":"<p>What if an existing drug could be repurposed to treat a rare disease?</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>That/news/wp-json/wp/v2/posts/155281/u2019s the question <a href=/news/wp-json/wp/v2/posts/155281/"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//research/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281/">Â鶹ӳ»­´«Ã½ researchers</news/wp-json/wp/v2/posts/155281//a> are exploring with the help of <a href=/news/wp-json/wp/v2/posts/155281/"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//artificial-intelligence/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281/">artificial intelligence</news/wp-json/wp/v2/posts/155281//a> (AI) to find a cure for rare nerve tumors that can cause paralysis, hearing and balance loss.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>Led by <a href=/news/wp-json/wp/v2/posts/155281/"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//college/news/wp-json/wp/v2/posts/155281//medicine/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281/">Â鶹ӳ»­´«Ã½ College of Medicine</news/wp-json/wp/v2/posts/155281//a> Pegasus Professor Cristina Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle, the team is investigating whether medications already approved by the U.S. Food and Drug Administration for other conditions could be swiftly repurposed to treat schwannoma tumors.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>The researchers have narrowed a field of about 200 potential drugs to 10 of interest, with three emerging as the most favorable targets.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>Their goal is to find new treatment options for patients with Neurofibromatosis type 2 (<em>NF2)</news/wp-json/wp/v2/posts/155281//em>-related schwannomatosis. The genetic disorder causes benign tumors to develop on nerves throughout the body and head. As the tumors grow, they can damage nerves responsible for movement and sensation, including those needed to hear and balance.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>The disease affects about one in 25,000 newborns worldwide, according to the Children/news/wp-json/wp/v2/posts/155281/u2019s Tumor Foundation, with symptoms often appearing during adolescence and early adulthood. When diagnosed in children, the disorder can be severe and may require multiple surgeries during puberty to reduce tumor size and prevent further loss of function. The Children/news/wp-json/wp/v2/posts/155281/u2019s Tumor Foundation is supporting Â鶹ӳ»­´«Ã½/news/wp-json/wp/v2/posts/155281/u2019s research with a $280,020 grant.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>/news/wp-json/wp/v2/posts/155281/u201cThe Children/news/wp-json/wp/v2/posts/155281/u2019s Tumor Foundation was critical to us because they fund the exploratory research that helps advance science,/news/wp-json/wp/v2/posts/155281/u201d Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle says. /news/wp-json/wp/v2/posts/155281/u201cAll of this foundational data is needed to attract the additional support needed to demonstrate a treatment holds real promise./news/wp-json/wp/v2/posts/155281/u201d</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<figure id=/news/wp-json/wp/v2/posts/155281/"attachment_155286/news/wp-json/wp/v2/posts/155281/" style=/news/wp-json/wp/v2/posts/155281/"max-width: 1200px;/news/wp-json/wp/v2/posts/155281/" 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alt=/news/wp-json/wp/v2/posts/155281/"A Â鶹ӳ»­´«Ã½ student uses a pipette while Â鶹ӳ»­´«Ã½ Professor Cristina Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle observes him in a research lab./news/wp-json/wp/v2/posts/155281/" srcset=/news/wp-json/wp/v2/posts/155281/"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//wp-content/news/wp-json/wp/v2/posts/155281//blogs.dir/news/wp-json/wp/v2/posts/155281//20/news/wp-json/wp/v2/posts/155281//files/news/wp-json/wp/v2/posts/155281//2026/news/wp-json/wp/v2/posts/155281//09/news/wp-json/wp/v2/posts/155281//Cristina-Valle-and-Ethan-Hass_-Schwannoma-research.jpg 1200w, 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1200px/news/wp-json/wp/v2/posts/155281/"></news/wp-json/wp/v2/posts/155281//noscript><img decoding=/news/wp-json/wp/v2/posts/155281/"async/news/wp-json/wp/v2/posts/155281/" width=/news/wp-json/wp/v2/posts/155281/"1200/news/wp-json/wp/v2/posts/155281/" height=/news/wp-json/wp/v2/posts/155281/"800/news/wp-json/wp/v2/posts/155281/" class=/news/wp-json/wp/v2/posts/155281/"figure-img img-fluid w-100 wp-image-155286 size-full lazyload/news/wp-json/wp/v2/posts/155281/" src=/news/wp-json/wp/v2/posts/155281/"data:image/news/wp-json/wp/v2/posts/155281//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/155281/" alt=/news/wp-json/wp/v2/posts/155281/"A Â鶹ӳ»­´«Ã½ student uses a pipette while Â鶹ӳ»­´«Ã½ Professor Cristina Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle observes him in a research lab./news/wp-json/wp/v2/posts/155281/" srcset=/news/wp-json/wp/v2/posts/155281/"data:image/news/wp-json/wp/v2/posts/155281//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w/news/wp-json/wp/v2/posts/155281/" sizes=/news/wp-json/wp/v2/posts/155281/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/155281/" data-srcset=/news/wp-json/wp/v2/posts/155281/"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//wp-content/news/wp-json/wp/v2/posts/155281//blogs.dir/news/wp-json/wp/v2/posts/155281//20/news/wp-json/wp/v2/posts/155281//files/news/wp-json/wp/v2/posts/155281//2026/news/wp-json/wp/v2/posts/155281//09/news/wp-json/wp/v2/posts/155281//Cristina-Valle-and-Ethan-Hass_-Schwannoma-research.jpg 1200w, 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https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//wp-content/news/wp-json/wp/v2/posts/155281//blogs.dir/news/wp-json/wp/v2/posts/155281//20/news/wp-json/wp/v2/posts/155281//files/news/wp-json/wp/v2/posts/155281//2026/news/wp-json/wp/v2/posts/155281//09/news/wp-json/wp/v2/posts/155281//Cristina-Valle-and-Ethan-Hass_-Schwannoma-research-600x400.jpg 600w, https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//wp-content/news/wp-json/wp/v2/posts/155281//blogs.dir/news/wp-json/wp/v2/posts/155281//20/news/wp-json/wp/v2/posts/155281//files/news/wp-json/wp/v2/posts/155281//2026/news/wp-json/wp/v2/posts/155281//09/news/wp-json/wp/v2/posts/155281//Cristina-Valle-and-Ethan-Hass_-Schwannoma-research-360x240.jpg 360w/news/wp-json/wp/v2/posts/155281/" data-src=/news/wp-json/wp/v2/posts/155281/"https:/news/wp-json/wp/v2/posts/155281///news/wp-json/wp/v2/posts/155281//www.ucf.edu/news/wp-json/wp/v2/posts/155281//wp-content/news/wp-json/wp/v2/posts/155281//blogs.dir/news/wp-json/wp/v2/posts/155281//20/news/wp-json/wp/v2/posts/155281//files/news/wp-json/wp/v2/posts/155281//2026/news/wp-json/wp/v2/posts/155281//09/news/wp-json/wp/v2/posts/155281//Cristina-Valle-and-Ethan-Hass_-Schwannoma-research.jpg/news/wp-json/wp/v2/posts/155281/"><figcaption class=/news/wp-json/wp/v2/posts/155281/"figure-caption/news/wp-json/wp/v2/posts/155281/">Pegasus Professor Cristina Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle observes Â鶹ӳ»­´«Ã½ College of Medicine M.D./news/wp-json/wp/v2/posts/155281//Ph.D.&nbsp;candidate Ethan Hass as he prepares medication samples for efficacy testing.</news/wp-json/wp/v2/posts/155281//figcaption></news/wp-json/wp/v2/posts/155281//figure>/news/wp-json/wp/v2/posts/155281/n<h2>Looking for Treatments Beyond Surgery</news/wp-json/wp/v2/posts/155281//h2>/news/wp-json/wp/v2/posts/155281/n<p>Schwann cells normally help repair nerves and transmit electrical signals throughout the nervous system. In patients with NF2, however, these cells can form visible tumors that cause chronic pain and neurological issues depending on the affected spinal or cranial nerve.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>Current treatments center on surgery and radiation, but removing these tumors can be challenging without damaging critical nerves, including those that affect hearing. Surgery also is not curative, as tumors can regrow.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>That/news/wp-json/wp/v2/posts/155281/u2019s why the research team is looking beyond surgery to potential drug therapies.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>While schwannomas are not cancerous, the researchers believe some cancer-fighting drugs may help patients with NF2.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>The research began with an AI model called TxGNN, used by Sage BioNetworks. The model analyzes data and biological mechanisms across thousands of diseases and FDA-approved drugs to identify potential treatments for a queried disease.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>/news/wp-json/wp/v2/posts/155281/u201cIt essentially generates a map for a disease or condition, like schwannomas, and finds overlaps in targeting similar pathways or related diseases,/news/wp-json/wp/v2/posts/155281/u201d says Ethan Hass, a Â鶹ӳ»­´«Ã½ College of Medicine M.D./news/wp-json/wp/v2/posts/155281//Ph.D. candidate working in the lab.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>Researchers at Sage Bionetworks used the TxGNN model to identify about 200 FDA-approved medications that could potentially benefit schwannoma patients. Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle/news/wp-json/wp/v2/posts/155281/u2019s team then used an innovative imaging system to observe how each drug affected human schwannoma cells.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>Using a camera inside a microscope, the team watched how schwannoma cells in a dish reacted to small amounts of each drug. The most promising candidates /news/wp-json/wp/v2/posts/155281/u2013 medications currently used to treat diseases as varied as lung cancer and acne /news/wp-json/wp/v2/posts/155281/u2013 stopped tumor cell growth by impacting different cellular mechanisms.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<h2>A Step Towards Personalized Treatment</news/wp-json/wp/v2/posts/155281//h2>/news/wp-json/wp/v2/posts/155281/n<p>The research continues.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>The Â鶹ӳ»­´«Ã½ scientists are determining therapeutic doses for the most promising drugs using patient-derived schwannoma cells. They/news/wp-json/wp/v2/posts/155281/u2019re also studying how the drugs affect the tumor growth pathways at the RNA level.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>Ultimately, the researchers hope their findings will help identify drug combinations tailored to individual patients. Complicated and understudied genetic conditions like <em>NF2-</news/wp-json/wp/v2/posts/155281//em>related schwannomatosis often require treatments that address multiple targets, Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle says.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>/news/wp-json/wp/v2/posts/155281/u201cI think this work is encouraging, and I/news/wp-json/wp/v2/posts/155281/u2019d say like with many cancers, you need a cocktail of drugs to treat it,/news/wp-json/wp/v2/posts/155281/u201d she says. /news/wp-json/wp/v2/posts/155281/u201cI think what we/news/wp-json/wp/v2/posts/155281/u2019re doing here is helping to identify some of the ingredients you might need to make an effective cocktail./news/wp-json/wp/v2/posts/155281/u201d</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<figure id=/news/wp-json/wp/v2/posts/155281/"attachment_155285/news/wp-json/wp/v2/posts/155281/" style=/news/wp-json/wp/v2/posts/155281/"max-width: 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class=/news/wp-json/wp/v2/posts/155281/"figure-caption/news/wp-json/wp/v2/posts/155281/">From left: Pegasus Professor Cristina Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle, biomedical sciences undergraduate students Alfonso Aviles and Amanda Nunez-Ferreira, materials science and engineering doctoral candidate Alex Sutton and M.D./news/wp-json/wp/v2/posts/155281//Ph.D. student Ethan Hass.</news/wp-json/wp/v2/posts/155281//figcaption></news/wp-json/wp/v2/posts/155281//figure>/news/wp-json/wp/v2/posts/155281/n<h2>From Lab Bench to Patient Bedside</news/wp-json/wp/v2/posts/155281//h2>/news/wp-json/wp/v2/posts/155281/n<p>The project also provides Â鶹ӳ»­´«Ã½ students with the opportunity to participate in research that can make a real-world impact.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>Since joining Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle/news/wp-json/wp/v2/posts/155281/u2019s lab, Hass says his interest in caring for patients with difficult neurologic conditions has grown.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n<p>/news/wp-json/wp/v2/posts/155281/u201cAs an M.D./news/wp-json/wp/v2/posts/155281//Ph.D. student, translation is the magic word for me,/news/wp-json/wp/v2/posts/155281/u201d he says. /news/wp-json/wp/v2/posts/155281/u201cI absolutely love seeing research that can be brought from the bench to the bedside. I want to be that bridge between patients and research./news/wp-json/wp/v2/posts/155281/u201d</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n","protected":false},"excerpt":{"rendered":"<p>Using artificial intelligence-generated data, Pegasus Professor Cristina Fern/news/wp-json/wp/v2/posts/155281/u00e1ndez-Valle and her team are screening existing FDA-approved drugs for their potential to treat schwannoma tumors.</news/wp-json/wp/v2/posts/155281//p>/news/wp-json/wp/v2/posts/155281/n","protected":false},"author":242,"featured_media":155284,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,12,17,23,24],"tags":[54138,979,8574,22543,14914,14916],"tu_author":[],"class_list":["post-155281","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-health","category-medicine","category-research","category-science-technology","tag-artificial-intelligence","tag-college-of-medicine","tag-cristina-fernandez-valle","tag-healthcare","tag-medicine","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v28.2) - 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