{"id":75368,"date":"2016-12-14T09:54:56","date_gmt":"2016-12-14T14:54:56","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=75368"},"modified":"2018-06-19T13:15:43","modified_gmt":"2018-06-19T17:15:43","slug":"natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\/","title":{"rendered":"Natural Killer Cell Technology to Stop Cancer Gets Licensed, On Way to Clinical Trials"},"content":{"rendered":"<p>Our bodies contain Natural Killer (NK) cells \u2013 an army that stops cancers and viruses before they can make us sick. A researcher from the Â鶹ӳ»­´«Ã½\u2019s College of Medicine has created a nanoparticle that increases the number of these killers 10,000-fold in the lab and her new technology has generated a licensing agreement that is expected to accelerate the therapy\u2019s path to clinical trials.<\/p>\n<p>Cyto-Sen Therapeutics Inc., a Florida-based start-up company created by NK researchers and physicians including Â鶹ӳ»­´«Ã½ researcher Alicja Copik and others at Â鶹ӳ»­´«Ã½, MD Anderson Cancer Center in Houston and Nationwide Children\u2019s Hospital in Columbus, Ohio, recently licensed the technology and plans to begin clinical trials by late 2017.<\/p>\n<p>On a computer screen in her lab, Copik\u2019s heightened killers literally <a href=\"https:\/\/www.youtube.com\/watch?v=Rbs7b9h7hlE\">eat cancer cells<\/a> before your eyes. \u201cYou realize how powerful this system is when you see these cells actually tearing apart the tumors,\u201d she said. \u201cThese Natural Killer cells are an army and they\u2019re your friends. This potential therapy means you have more of these fighters and they are armed to the teeth.\u201d<\/p>\n<p>NK cells play an important first-line-of-defense in fighting all foreign cells in the body. Dr. Dean Lee, director of cellular therapy and cancer immunology at Nationwide, serves as medical director and vice president of Cyto-Sen. He said medicine had known very little about NK cells until researchers were able to identify and grow them in the late 1990s. Since then, more research is focusing on NK cell therapies for cancers including lymphoma, leukemia and even brain, ovarian and breast cancers. Previous studies attempted to use other types of cells, even tumor cells, to encourage NK cells to grow. But those therapies were commercially cumbersome and had serious side effects for patients in clinical trials.<\/p>\n<p>Â鶹ӳ»­´«Ã½\u2019s technology uses nanoparticles that signal the NK cells to reproduce and arm themselves to fight the cancer. In Copik\u2019s lab, one NK cell taken from a patient and contacted by the nanoparticle yielded 10,000 new cells in two weeks. \u201cÂ鶹ӳ»­´«Ã½\u2019s discovery has really solved a key problem that makes NK cell therapies more accessible to all,\u201d Lee said. \u201cWe are very excited about the possibilities.\u201d If the technology can be safely manufactured and is effective in clinical trials, it could allow any hospital that provides cell therapies such as bone marrow transplants to create their own advanced NK cells on-site for cancer patients, he said.<\/p>\n<p>Phil McKee, chairman of Cyto-Sen, has a personal reason for supporting Copik\u2019s work. The physicist\/inventor needed chemotherapy and a bone marrow transplant to cure his blood cancer and wants to create more natural therapies that beat the disease \u2013 without severe side effects.<\/p>\n<p>\u201cDr. Copik\u2019s delivery-expansion method appears to create an important bridge between our desire to use the body\u2019s own cancer-fighting systems and medical science\u2019s ability to make that happen in the lab,\u201d he said. \u201cWith her system, we can take what the body naturally has and instead of a few soldiers, we can create a battalion.\u201d<\/p>\n<p>The therapy has shown effectiveness in treating acute myeloid leukemia, a cancer of blood-forming tissues including bone marrow. Further study could develop nanoparticles with signals for specific cancers and viruses such as Ebola or HIV, Lee and Copik said.<\/p>\n<p>Lee will lead the manufacturing effort at Nationwide\u2019s cGMP (current Good Manufacturing Practices) facility, which is required to meet the strict quality and safety standards set by the U.S. Food and Drug Administration for creating medical therapies for humans.<\/p>\n<p>Copik\u2019s NK cell research was supported by two $400,000 grants from the Florida Department of Health\u2019s Bankhead-Coley Cancer Research Program. She said her love of science was inspired by her father, an engineer in her native Poland who created automated mechanical locks and door openings to improve safety for coal miners.<\/p>\n<p>\u201cMy mother was always proudly showing me pictures of his inventions,\u201d she said. \u201cThat\u2019s where I got my curiosity, my passion for developing new things, asking questions and solving problems.\u201d<\/p>\n<p>She received her Ph.D. in biochemistry at Utah State University, did post-doctoral work at the University of Texas Medical Branch and Roche Pharmaceuticals, and worked at Florida Hospital before coming to Â鶹ӳ»­´«Ã½. The NK cell technology is a credit to a multidisciplinary team of researchers, immunologists, biochemists and physicians working with the College of Medicine to find better ways to help cancer patients, she said.<\/p>\n<p>\u201cSo many people have worked together to get us to this point,\u201d she said. \u201cAs a researcher you dedicate your life to science. To be able to see your idea go from your lab to actual clinical trials that can help patients is a dream come true.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"Our bodies contain Natural Killer (NK) cells \u2013 an army that stops cancers and viruses before they can make us sick. A researcher from the Â鶹ӳ»­´«Ã½\u2019s College of Medicine has created a nanoparticle that increases the number of these killers 10,000-fold in the lab and her new technology has generated a licensing agreement that is expected to&hellip;","protected":false},"author":16,"featured_media":75369,"comment_status":"open","ping_status":"closed","sticky":false,"template":"template-twocol.php","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,6,12,27],"tags":[15972,3280,15761,202],"tu_author":[],"class_list":["post-75368","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-community","category-health","category-student-life","tag-alicja-copik","tag-nanotechnology","tag-pegasus-briefs","tag-alumni"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Natural Killer Cell Tech to Stop Cancer Gets Licensed, Clinical Trials<\/title>\n<meta name=\"description\" content=\"Our bodies contain Natural Killer (NK) cells \u2013 an army that stops cancers and viruses before they can make us sick. A researcher from the University of\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ucf.edu\/news\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Natural Killer Cell Technology to Stop Cancer Gets Licensed, On Way to Clinical Trials\" \/>\n<meta property=\"og:description\" content=\"Our bodies contain Natural Killer (NK) cells \u2013 an army that stops cancers and viruses before they can make us sick. A researcher from the University of\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ucf.edu\/news\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\/\" \/>\n<meta property=\"og:site_name\" content=\"Â鶹ӳ»­´«Ã½ News | Â鶹ӳ»­´«Ã½ Today\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Â鶹ӳ»­´«Ã½\" \/>\n<meta property=\"article:published_time\" content=\"2016-12-14T14:54:56+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-06-19T17:15:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2016\/12\/Copik.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"682\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Zenaida Kotala\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Â鶹ӳ»­´«Ã½\" \/>\n<meta name=\"twitter:site\" content=\"@Â鶹ӳ»­´«Ã½\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Zenaida Kotala\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/\"},\"author\":{\"name\":\"Zenaida Kotala\",\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/#\\\/schema\\\/person\\\/4f0fdedfa744a8bfddd06132e6ce9b5e\"},\"headline\":\"Natural Killer Cell Technology to Stop Cancer Gets Licensed, On Way to Clinical Trials\",\"datePublished\":\"2016-12-14T14:54:56+00:00\",\"dateModified\":\"2018-06-19T17:15:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/\"},\"wordCount\":796,\"commentCount\":1,\"image\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ucf.edu\\\/wp-content\\\/blogs.dir\\\/20\\\/files\\\/2016\\\/12\\\/Copik.jpg\",\"keywords\":[\"Alicja Copik\",\"nanotechnology\",\"Pegasus Briefs\",\"Â鶹ӳ»­´«Ã½ Alumni\"],\"articleSection\":[\"Colleges &amp; Campus\",\"Community\",\"Health &amp; Medicine\",\"Student Life\"],\"inLanguage\":\"en-US\",\"copyrightYear\":\"2016\",\"copyrightHolder\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/\",\"url\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/\",\"name\":\"Natural Killer Cell Tech to Stop Cancer Gets Licensed, Clinical Trials\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/natural-kill-cell-technology-stop-cancer-gets-licensed-way-clinical-trials\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ucf.edu\\\/wp-content\\\/blogs.dir\\\/20\\\/files\\\/2016\\\/12\\\/Copik.jpg\",\"datePublished\":\"2016-12-14T14:54:56+00:00\",\"dateModified\":\"2018-06-19T17:15:43+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/#\\\/schema\\\/person\\\/4f0fdedfa744a8bfddd06132e6ce9b5e\"},\"description\":\"Our bodies contain Natural Killer (NK) cells \u2013 an army that stops cancers and viruses before they can make us sick. 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